复方丹参滴丸治疗老年心衰患者后血浆pro-BNP表达变化研究

Clinical effect of compound Danshen dropping pills for the elderly patients with heart failure and its influence on the plasma pro-BNP

目的:探讨复方丹参滴丸治疗老年心力衰竭(心衰)的临床疗效及对患者血浆B型利钠肽前体(proBNP)水平的影响。方法:将92例老年心衰患者随机分成对照组与观察组,每组46例。其中对照组给予常规西医治疗,观察组在对照组的基础上加用复方丹参滴丸10粒/次,3次/天,2组疗程均为6个月。观察并记录2组患者治疗前及治疗1、3、6个月后血浆pro-BNP水平变化情况,治疗6个月后的临床疗效及治疗期间不良反应的发生情况。结果:对照组治疗6个月后的血浆pro-BNP水平显著低于治疗前,差异有统计学意义;观察组治疗3、6个月后的血浆pro-BNP水平均显著低于治疗前,同时也显著低于对照组,差异有统计学意义;治疗6个月后观察组的临床疗为91.3%效显著优于对照组76.1%,差异有统计学意义。结论:复方丹参滴丸治疗老年心衰能够有效降低患者的血浆pro-BNP水平,且疗效显著,安全可靠。

Objective To investigate the clinical effect of compound Danshen dropping pills therapy in patients with congestive hearts failure, and to analysis its effect on the plasma pro-BNP. Methods Ninety-two patients with congestive hearts failure were randoly divided into control group and observation group, each group 46 cases. The control group were treatment by routine western medicine, and the observation group were treatment by compound Danshen dropping pills 10 pills one time, 3 times one day, one course of the treatment of each group is six months. Then observed and recorded the level of the plasma proBNP before and one, three, six months after treatment, the clinical effect and the adverse reaction. Results In the control group, six months after treatment, the level of the plasma pro-BNP was significantly lower than that before treatment, a statistically significant difference. In observation group, three and six months after treatment, these levels of the plasma pro-BNP were significantly lower than those before treatment, and also significantly lower than those in the control group, a statistically significant difference. Six months after treatment, the total efficacy rates of the observation group(91.3%) was significantly higher than that in the control group(76.1%), a statistically significant difference. Conclusion Compound Danshen dropping pills can effectively reduce the level of the plasma pro-BNP, enhance the clinical effect, safe and reliable.