尤靖安、膦甲酸钠及其联合治疗HPV感染的临床研究

Clinical study of Youjing'an, foscarnet sodium and their combination in the treatment of HPV infection

目的:比较尤靖安、膦甲酸钠及二者联合治疗HPV感染的临床疗效,探析HPV感染临床治疗的理想方案。方法:选取我院门诊2014年1月~2016年8月共收治的96例HPV感染患者作为研究对象,按随机数字表将入选患者分为A、B、C三组,各32例。A组采取尤靖安(重组人干扰素α2b凝胶)进行治疗,B组采取单纯膦甲酸钠氯化钠注射液进行治疗,C组采用尤靖安与膦甲酸钠氯化钠注射液联合治疗。比较三组治疗前后宫颈炎指标评分、HPV转阴率及治疗总有效率。结果:三组治疗前宫颈炎指标评分的两两比较均无统计学意义;治疗后A、B、C组的宫颈炎指标评分分别降低至(2.5±0.6)分、(2.7±0.7)分、(1.1±0.4)分,与治疗前比较有统计学意义;同时C组评分低于A组与B组,A组与B组之间则无统计学差异。A组总转阴率为68.8%(22/32),B组为65.6%(21/32),差异无统计学意义;C组总转阴率为90.6%(29/32)。A组总有效率为78.1%(25/32),B组为75.0%(24/32),差异无统计学意义;C组总有效率为96.9%(31/32),高于A组与B组,差异均有统计学意义。结论:尤靖安联合膦甲酸钠治疗HPV感染可发挥全面抗病毒作用,并增强药物活性、强化抗HPV感染的疗效,较之单纯尤靖安及单纯膦甲酸钠治疗效果明显更佳。

Objective To compare the clinical efficacy of Youjing'an, foscarnet sodium and their combination in the treatment of HPV infection, and explore the ideal treatment for HPV infection. Methods A total of 96 patients with HPV infection who were admitted to our hospital from January 2014 to August 2016 were selected as the study subjects and the patients were divided into A, B, C three groups by the random number table method, 32 cases in each group. Group A were treated with Youjing'an(recombinant human interferon alpha 2 b gel), group B were treated with simple foscarnet sodium and sodium chloride injection and group C were treated with Youjing'an combined with foscarnet sodium and sodium chloride injection. The scores of cervicitis indexes, negative conversion rate of HPV and the total efficiency of treatment were compared among the three groups. Results There was no statistically significant difference among the three groups in scores of cervicitis indexes before treatment. After treatment, scores of cervicitis indexes in group A group B and group C were reduced to(2.5±0.6) points,(2.7±0.7) points and(1.1±0.4) points, and the scores were lower in group C than group A and group B while there was no significant difference between group A and group B. The total negative conversion rate showed no significant difference between group A and group B [68.8%(22/32) vs 65.6%(21/32) ] and total negative conversion rate was 90.6%(29/32) in group C. The total effective rate showed no significant difference between group A and group B [78.1%(25/32) vs 75.0%(24/32) ]. The total effective rate of group C [96.9%(31/32) ] was higher than group A and group B. Conclusion Youjing'an combined with foscarnet sodium in the treatment of HPV infection may play a full antiviral effect. It can enhance drug activity and strengthen the effect of antiHPV infection. Compared with simple Youjing'an or foscarnet sodium, the efficacy is better.