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低分子肝素钙预防剖宫产术后深静脉血栓形成的临床价值分析 被引量:10

Clinical value of low molecular weight heparin calcium in prevention of deep vein thrombosis after cesarean section
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摘要 目的:观察低分子肝素钙预防剖宫产术后深静脉血栓形成的临床价值。方法:选择2016年1月~2016年12月~我院进行剖宫产手术的产妇188例进行研究。随机分为观察组和对照组各94例,对照组产妇术后不给予抗凝治疗,观察组产妇术后6h时候低分子肝素钙5000IU,日一次,皮下注射,共计5d。所有产妇在术前和术后第4d取空腹静脉血,对D-二聚体、纤维蛋白原、活化部分凝血酶时间(APTT)、凝血酶原时间、血小板(PLT)等指标进行检测,观察其变化情况。术后7d对所有患者进行双下肢深静脉发生率检查。结果:两组患者术前D-二聚体、纤维蛋白原、PT、APTT、PLT均无明显差异,术后4d观察组D-二聚体、纤维蛋白原明显低于对照组,且具有统计学差异,但PT、APTT、PLT与对照组无明显差异,观察组无下肢深静脉血栓形成,对照组发生率为6.38%;观察组下肢发生疼痛肿胀1.06%、对照组未8.51%。观察组下肢深静脉血栓形成发生率与下肢疼痛、肿胀发生率均明显高于对照组,且具有统计学差异。结论:低分子肝素钙杜宇预防剖宫产术后深静脉血栓形成具有重要的临床应用价值,且不会对产妇术后的凝血时间、血小板等指标发生影响,效果安全可靠。 Objective To observe the clinical value of low molecular weight heparin calcium in prevention of deep vein thrombosis after cesarean section. Methods 188 cases of cesarean section from January 2016-2016 to our hospital in December were studied. The patients were randomly divided into the observation group and the control group with 94 cases in each group. The control group was not given anticoagulant treatment after the operation. The observation group was given low molecular weight heparin calcium 5000 IU at 6 h after the operation, and once a day, subcutaneous injection, totaling 5 d. All the mothers in the preoperative and postoperative 4 D fasting venous blood, the D-two dimer, fibrinogen, activated partial thromboplastin time(APTT), prothrombin time and platelet(PLT) were detected and observed. The incidence of deep venous thrombosis in both lower extremities was examined in all patients after 7 d. Results Two groups of patients before D-two dimer, fibrinogen, PT, APTT and PLT showed no significant difference, 4 D after the operation, the observation group two D-dimer and fibrinogen was significantly lower than the control group, and the difference was statistically significant, but PT, APTT, PLT and control group no significant difference, the observation group had no deep venous thrombosis, the incidence rate was 6.38% in control group; the observation group had lower extremity pain and swelling in 1.06%, the control group was 8.51%. The incidence of deep vein thrombosis and the incidence of lower limb pain and swelling in the observation group were significantly higher than those in the control group, and there was a statistical difference. Conclusion Low molecular weight heparin to prevent Du Yu cesarean section postoperative deep venous thrombosis has important clinical application value, and not on the maternal postoperative clotting time, platelet index influence effect, safe and reliable.
出处 《湖南师范大学学报(医学版)》 2018年第1期19-22,共4页 Journal of Hunan Normal University(Medical Sciences)
基金 河北省卫生厅科研基金项目(N0.08247)
关键词 低分子肝素钙 剖宫产 深静脉血栓形成 low molecular weight heparin calcium cesarean section deep vein thrombosis
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