还原型谷胱甘肽对慢性肺心病急性加重期抗氧化功能的影响分析

Effect of reduced glutathione on antioxidant function in patients with chronic cor pulmonale at acute exacerbation stage

目的:研究还原型谷胱甘肽对慢性肺心病急性加重期抗氧化功能的影响。方法:选取2016年1月~2017年6月我院接诊的80例慢性肺心病急性加重期患者进行研究。按照随机数表法,随机均分为研究组和对照组。对照组给予患者化痰平喘、规律吸氧治疗。研究组在对照组治疗基础上,联合应用还原型谷胱甘肽进行治疗。治疗前后,比较分析两组患者的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、血浆脂质过氧化物(Lipid peroxide,LPO)、丙二醛(MDA)及过氧化氢酶(CAT)水平,并对患者治疗后的疗效及转归状况进行调查分析。结果:治疗后,研究组患者的SOD、GSH-Px及CAT水平均显著升高,LPO及MDA水平均显著降低,且两组数据比较有显著性差异。研究组患者的右心室压及平均肺动脉压水平均显著降低,且研究组明显低于对照组,两组比较有统计学意义。研究组治疗的总有效率(87.50%)明显高于对照组(70.00%),两组比较有统计学意义。研究组患者的急性肾衰发生率(7.50%)明显低于对照组(25.00%),两组多器官功能障碍综合征(Multiple organ dysfunction Syndrome,MODS)及死亡发生率无显著性差异。结论:还原型谷胱甘肽可显著改善慢性肺心病急性加重期抗氧化功能,提高疗效,改善患者预后状况,值得广泛应用。

Objective To study the effect of reduced glutathione on antioxidant function in patients with chronic cor pulmonale at acute exacerbation stage. Methods 80 patients with acute exacerbation of chronic pulmonary heart disease from January 2016 to June 2017 were investigated in our hospital. According to the random number table method, were randomly divided into study group and control group. The patients in control group were given expectorant, antiasthmatic and regular oxygen therapy. The study group was treated with reduced glutathione on the basis of the treatment of the control group. Before and after the treatment, the SOD, GSH-Px, LPO, MDA and CAT level of the two groups were compared and analyzed, and the curative effect of the patients after treatment the investigation and analysis of status and prognosis. Results After treatment, the levels of SOD, GSH-Px and CAT in patients in the study group were significantly increased, the levels of LPO and MDA were significantly lower, and there was a significant difference between the two groups. The average right ventricular pressure and mean pulmonary arterial water pressure in the study group decreased significantly, and the study group was significantly lower than the control group, the two groups were statistically significant. The total effective rate of the treatment group(87.50%) was significantly higher than that of the control group(70%), and the difference between the two groups was statistically significant. The incidence of acute renal failure in the study group(7.50%) was significantly lower than that in the control group(25%), and there was no significant difference in the incidence of MODS and death between the two groups. Conclusion Reduced glutathione can significantly improve the antioxidant function in patients with chronic cor pulmonale at acute exacerbation stage, improve the curative effect and improve the prognosis of patients with chronic pulmonary heart disease, and is worthy of wide application.