促甲状腺激素水平对妊娠期高血压综合征产妇妊娠结局的影响

Effect of Thyroid Stimulating Hormone Level on Maternal Pregnancy Outcome in Pregnancy-induced Hypertension Syndrome

目的:探讨分析促甲状腺激素检测水平对妊娠期高血压综合征产妇妊娠结局的影响。方法:随机选取2016年4月~2017年1月在我院住院分娩的单胎妊娠高血压综合征患者96例作为本次研究对象,根据促甲状腺激素(TSH)水平分为对照组(TSH<3.0m IU/L,48例)和观察组(TSH≥3.0m IU/L,48例),统计比较两组血清FT3、FT4及TSH水平、免疫功能(Ig A、Ig M、Ig G)、妊娠结局及围产新生儿结局情况。结果:观察组患者的TSH水平明显高于对照组,三碘甲状腺原氨酸(FT3)、游离甲状腺激素(FT4)水平较低,差异有统计学意义;观察组患者的免疫功能指标水平(Ig A、Ig M、Ig G)低于对照组,差异有统计学意义;观察组早产、胎膜早破、产后出血发生率明显高于对照组,差异有统计学意义;两组胎儿宫内窘迫、剖宫产发生率比较,差异无统计学意义;观察组新生儿窒息、呼吸窘迫综合征及黄疸发生率均高于对照组,差异有统计学意义;两组新生儿感染发生率比较[0.00%vs 0.00%],差异无统计学意义。结论:促甲状腺激素水平升高将增加妊娠期高血压综合征患者胎膜早破、早产及产后出血发生率,降低自身免疫功能,进而增加新生儿窒息、呼吸窘迫综合征及黄疸的发病风险,值得临床给予足够的重视。

Objective To investigate the effect of Thyroid Stimulating Hormone(TSH) on pregnancy outcome in pregnant women with hypertensive syndrome.Methods 96 cases of patients with monozygotic pregnancy-induced hypertension were enrolled in our hospital from April 20 to January 2017, and were divided into control group(TSH<3.0 m IU/L, 48 cases) and observation group(TSH≥3.0 m IU/L, 48 cases) according to the TSH level.The serum FT3, FT4 and TSH levels, immunological function(Ig A, Ig M, Ig G), pregnancy outcome and neonatal outcome were compared between the two groups. Results The level of TSH in the observation group was significantly higher than that in the control group, the levels of triiodothyronine(FT3) and free thyroid hormone(FT4) were lower, the difference was statistically significant. The levels of immune function(Ig A, Ig M, Ig G) in the observation group were significantly lower than those in the control group.The incidence of premature delivery, premature rupture of membranes and postpartum hemorrhage was significantly higher in the observation group than in the control group.There was no significant difference in the incidence of intrauterine distress and cesarean section between the two groups.The incidence of neonatal asphyxia, respiratory distress syndrome and jaundice in the observation group was significantly higher than that in the control group.The incidence of neonatal infection in both groups was [0.00% vs 0.00%], the difference was not statistically significant. Conclusion TSH levels in patients with gestational hypertension will increase the incidence of premature rupture of membranes, premature birth and postpartum hemorrhage, reduce autoimmune function, thereby increasing the risk of neonatal asphyxia, respiratory distress syndrome and jaundice, worthy of clinical Give enough attention.