门冬氨酸钾镁联合治疗在急性心肌梗死室性心律失常中的应用研究

Application in acute myocardial infarction ventricular arrhythmias in the combined treatment of Potassium Aspartate magnesium

目的:观察门冬氨酸钾镁联合胺碘酮对急性心肌梗死室性心律失常的治疗效果。方法:以2014年5月~2015年5月在我院接受治疗的80例急性心肌梗死并室性心律失常的患者为观察对象,并将其随机分为对照组和观察组,每组各40例患者,其中对照组给予胺碘酮治疗,观察组给予门冬氨酸钾镁联合胺碘酮治疗。观察两组患者的治疗效果、治疗后胸痛复发及治疗期间心律失常的发生情况;比较两组患者治疗前后心功能的指标及不良反应发生率。结果:经过治疗,观察组的显效例数明显多于对照组,无效例数少于对照组;治疗后观察组胸痛复发及心衰加重的发生率明显较对照组少,两组患者肝肾功能异常和低血压的发生率无明显差别;观察组患者在治疗期间室颤、室扑和室上速的发生率明显较对照组低;两组患者治疗前SV、NT-pro BNP、CTnl、LVPS、LVEF水平无明显差异,经过治疗后,两组患者的SV、LVPS、LVEF水平升高,NT-pro BNP、CTnl下降,而观察组上述指标的改善较对照组更为明显。结论:门冬氨酸钾镁联合胺碘酮对急性心肌梗死室性心律失常有较好的治疗效果,可降低治疗期间心律失常和治疗后不良反应的发生率,且对心功能的改善也有一定的促进作用,具有临床应用价值。

Objective To observe the therapeutic effect of Potassium Aspartate magnesium combined with amiodarone on acute myocardial infarction ventricular arrhythmias. Methods 80 patients with acute myocardial infarction and ventricular arrhythmia treated in our hospital from May 2014 to May 2015 were selected and randomly divided into control group and observation group, 40 cases in each group. The control group was treated with amiodarone treatment, the observation group was given Potassium Aspartate magnesium combined with amiodarone. Observe the efficiency, the recurrence of chest pain after treatment and the incidence of arrhythmia in the two groups and compared the heart function and adverse reaction rate. of the two groups before and after treatment. Results After treatment, the number of markedly effective cases in the observation group was significantly more than that in the control group, and the number of invalid cases was less than that in the control group. After treatment, the incidence of chest pain and heart failure in the observation group was significantly lower than that in the control group, and there was no significant difference between the two groups. The atrial fibrillation, supraventricular tachycardia attack in observation group during treatment was significantly lower than the control group. The level of NT-pro BNP, CTnl, LVPS, LVEF and SV had no significant difference in the two groups before treatment, after treatment, the level of LVPS, LVEF and SV increased, CTnl and NT-pro BNP decreased, while the improvement of the observation group was more obvious than that in the control group. Conclusion Potassium magnesium aspartate combined with amiodarone on acute myocardial infarction ventricular arrhythmias has good treatment effect, which can reduce the incidence of adverse reactions during treatment and improve the heart function, which has great linical application value.