丁苯酞对脑梗死患者神经功能、氧化应激及血流动力学的影响

Effects of butylphthalide on neurological function, oxidative stress and hemodynamics in patients with cerebral infarction

目的 :研究丁苯酞对脑梗死患者神经功能、氧化应激及血流动力学的影响。方法 :回顾性分析2016年6月~2017年6月120例就诊于我院的脑梗死患者,按随机分组原则分为常规组(60例)和研究组(60例),常规组接受常规对症治疗,研究组在接受常规治疗基础上加用丁苯酞,分析比较两组临床疗效和治疗前后神经功能、氧化应激及血流动力学变化情况。结果 :研究组总有效率为96.6%,显著优于常规组;治疗前常规组、研究组CSS评分无统计学差异,治疗3周后常规组、研究组CSS评分较治疗前均有所下降,但是研究组CSS评分下降水平较常规组更显著;治疗前常规组、研究组血清MDA、CAT、SOD水平无统计学差异,治疗3周后常规组、研究组血清MDA水平较治疗前均有所下降,但是研究组血清MDA下降水平较常规组更显著,治疗3周后常规组、研究组血清CAT、SOD水平较治疗前均有所上升,但是研究组血清CAT、SOD上升水平较常规组更显著;治疗前常规组、研究组血清NGF、NSE、NTF水平无统计学差异,治疗3周后常规组、研究组血清NSE水平较治疗前均有所下降,但是研究组血清NSE下降水平较常规组更显著,治疗3周后常规组、研究组血清NGF、NTF水平较治疗前均有所上升,但是研究组血清NGF、NTF上升水平较常规组更显著;两组治疗前收缩期血流速度(Vs)、平均血流速度(Vm)、搏动指数(PI)无统计学差异,治疗后两组收缩期血流速度、平均血流速度均上升,搏动指数下降,但是研究组收缩期血流速度、平均血流速度上升程度显著优于常规组,研究组搏动指数下降水平显著优于常规组。结论 :丁苯酞治疗脑梗死安全有效,其机制可能与提高患者脑部血液流动学水平及神经营养相关因子分泌,抑制氧化应激反应,修复受损神经功能有关。

Objective To study the effects of Butyphthalide on neurological function, Oxidative Stress and hemodynamics in Patients with Cerebral Infarction. Methods Retrospective analysis from June 2016 to June 2017 in 120 cases of patients with cerebral infarction in our hospital, regular group(60 cases) and study group(60 cases) according to the principle of random grouping, the rats in the conventional group were treated with conventional butt phthalide, and the clinical efficacy and neurological function, oxidative stress and hemodynamic changes were analyzed and compared before and after treatment. ResultsThe total effective rate was96.6% in the study group, significantly better than the conventional group, There was no significant difference in the CSS scores between the two groups. After 3 weeks of treatment, the CSS scores of the regular group and the study group decreased as compared with those before treatment, but the decline of the CSS score of the study group was more significant than that of the conventional group. There was no significant difference in serum MDA, CAT, SOD between the two groups before and after treatment. After 3 weeks of treatment, the level of MDA in study group decreased, The level was more significant than the conventional group. Before treatment, there was no significant difference in serum NGF, NSE and NTF between study group and control group. After 3 weeks of treatment, serum NSE level of study group was lower than that of routine group and study group. After 3 weeks of treatment, the levels of serum NGF and NTF in the routine group and the study group increased compared with those before treatment, but the levels of NGF and NTF in the study group were significantly higher than those in the conventional group. The systolic blood flow velocity(Vs), mean blood flow velocity(Vm) and pulsatility index(PI)of two groups before treatment did not differ significantly. After treatment, systolic blood flow velocity, mean blood flow velocity. The pulsatility index of the study group was significantly lower than that of the conventional group. Conclusion The innovative point of this paper is to observe the effects of butylphthalide on the neurological function, oxidative stress and hemodynamics in addition to observing the clinical efficacy of butylphthalide in patients with cerebral infarction and to explore the possible mechanisms involved in the treatment of cerebral infarction with butylphthalide.