肝硬化自发性腹膜炎患者经验性抗生素治疗疗效比较

Comparison of empiric antibiotic therapy in patients with cirrhosis and spontaneous bacterial peritonitis

目的 :观察社区感染肝硬化自发性腹膜炎患者使用比阿培南、哌拉西林舒巴坦、头孢噻肟作为初始治疗的临床疗效。方法 :回顾性分析560例社区感染肝硬化自发性腹膜炎患者分别经比阿培南、哌拉西林舒巴坦、头孢噻肟作为初始经验治疗,疗程均为7天,治疗结束后观察各组治疗效果。结果 :比阿培南组、哌拉西林舒巴坦组及头孢噻肟组总有效率及病死率无显著差异。结论 :比阿培南、哌拉西林舒巴坦、头孢噻肟均可作为社区感染肝硬化自发性腹膜炎患者的初始经验治疗。

Objective To observe the clinical efficacy of biapenem, piperacillin-sulbactam and cefotaxime as initial empirical treatment in community-acquired spontaneous bacterial peritonitis(SBP) with cirrhosis. Methods A retrospective analysis of 560 community-acquired cirrhosis patients with spontaneous bacterial peritonitis were treated with Biapenem, Piperacillin Sulbactam, Cefotaxime as the initial experience for 7 days, respectively, and to observe the effect of each group. Results The total efficacy and mortality rate between the three groups have no significant differences. Conclusion Biapenem, piperacillin-sulbactam and cefotaxime are all recommended as the initial empirical treatment in community-acquired SBP patients with cirrhosis.