β2-微球蛋白、C反应蛋白及乳酸脱氢酶检测在多发性骨髓瘤诊治中的临床意义

Clinical significance of diagnosis of β2-MG, CRP and LDH in the patients with multiple myeloma

目的 :探讨β2微球蛋白(β2-MG)、C反应蛋白(CRP)、乳酸脱氢酶(LDH)多发性骨髓瘤诊治中的临床意义。方法 :选择2009年11月～2015年5月医院门诊及住院接诊的40例多发性骨髓瘤患者作为观察组(根据ISS分期,其中Ⅰ期15例,Ⅱ期17例,Ⅲ期8例),并选择同期正常门诊体检者25例作为对照。抽取所有受试者空腹静脉血5ml,使用速率法检测LHD,免疫比浊法检测β2-MG,散射比浊法检测CRP,比较各组β2-MG、CRP、LDH的表达水平。结果 :观察组β2-MG、CRP、LDH水平均明显高于对照组;在观察组中,随着疾病ISS分期增高,β2-MG、CRP、LDH水平均显著升高;选取15例患者经过1个或2个化疗周期治疗后,观察组β2-MG、CRP、LDH均显著降低,和治疗前比较均具有明显差异。结论 :血清β2-MG、CRP、LDH在多发性骨髓瘤患者中表达明显较高,在诊断分期、治疗预后中应用价值高。

Objective To study clinical significance of diagnosis and treatment of β2-microglobulin(β2-MG), C reactive protein(CRP) and lactate dehydrogenase(LDH), in the patients with multiple myeloma. Methods Forty patients with multiple myeloma who underwent hospital outpatients and hospital admissions from November 2009 to May 2015 were enrolled as an observation group(15 cases of stage Ⅰ, 17 cases of stage Ⅱ and 8 cases of stage Ⅲ) Twenty-five normal subjects were selected as controls. The expression of β2-MG, CRP and LDH in the control group were detected by immunohistotrimination, and the expression ofβ2-MG, CRP and LDH were detected by immuno-turbidimetric assay. Results The levels of β2-MG, CRP and LDH in the observation group were significantly higher than those in the control group. The levels of β2-MG, CRP and LDH were significantly increased in the observation group. Fifteen patients in the observation group were treated with one or two chemotherapy cycles, the levels of β2-MG, CRP and LDH in the observation group were significantly lower than those before treatment. Conclusion The serum levels of β2-MG, CRP and LDH were significantly higher in patients with multiple myeloma, it have high application value in early diagnosis, curative effect evaluation and prognosis evaluation.