宫缩应激试验对胎儿生长受限孕妇外周血pH及脐动脉氧分压指标的影响及关联性分析

Effect andassociation analysisof contraction stress test on peripheral blood pH and umbilical artery oxygen partial pressure in pregnant women with fetal growth restriction

目的 :本研究是为了探讨宫缩应激试验(contraction stress test,CST)对胎儿生长受限(fetal growth restriction,FGR)孕妇外周血pH及脐动脉氧分压指标的影响及关联性分析。方法 :研究回顾性的分析2016年1月～2018年4月期间于我院妇产科就诊的妊娠第33～40周且明确诊断为胎儿生长受限的89名孕妇,其中包括接受宫缩应激试验的38名孕妇及未接受宫缩应激试验的51名孕妇。比较两组孕妇的新生儿结果(出生体重,Apgar评分,新生儿死亡率,新生儿重症监护病房住院率)、脐动脉PH值及血氧分压。结果 :两组新生儿结果(出生体重,Apgar评分,新生儿死亡率,新生儿重症监护病房住院率)均无显着差异。CST组的脐动脉pH为7.25±0.03,而未接受CST组的脐动脉pH为7.30±0.03,差异无统计学意义。CST组的脐动脉血氧分压值为22.1±8.3mmHg,而未接受CST组的脐动脉血氧分压值为14.8±5.0 mmHg,差异有统计学意义。结论 :CST对胎儿生长受限孕妇的外周血pH及新生儿结局无显著影响,却可明显改善脐动脉血氧分压。对于胎儿生长受限孕妇的来说,应用CST可在胎儿发生缺氧之前进行早期干预来改善胎儿预后。

Objective This study was designed to investigate the effect of contraction stress test(CST)onperipheral blood pH and umbilical artery oxygen partial pressure in fetal growth restriction(FGR)pregnant women and their association analysis.Methods A retrospective analysis of 89 pregnant women who were diagnosed with fetal growth restriction at the 33~40 weeks in gestational obstetrics and gynecology clinic of our hospital between January 2016 and April 2018 was performed.38 pregnant women wasundergoing CST and 51 pregnant women was not.The neonatal outcomes(birth weight,Apgar score,neonatal mortality,neonatal intensive care unit hospitalization rate),umbilical artery pH,and partial pressure of oxygen were compared in two groups.Results There were no significant differences in neonatal outcomes(birth weight,Apgar score,neonatal mortality,neonatal intensive care unit hospitalization rate)between the two groups.The umbilical artery pH in the CST group was 7.29±0.05,whereas the umbilical artery pH in the non-CST group was 7.31±0.04.The difference was not statistically significant.The umbilical arterial oxygen partial pressure in the CST group was 22.3±8.5 mmHg,whereas the umbilical arterial oxygen partial pressure in the non-CST group was 14.9±6.0 mmHg.The difference was statistically significant.Conclusion CST has no significant effect on peripheral blood pH and neonatal outcome in pregnant women with fetal growth restriction,but it can significantly improve the oxygen pressure in umbilical arteries.For pregnant women with fetal growth restriction,the use of CST can provide early intervention before hypoxia to improve prognosisoffetus.