血清同型半胱氨酸联合hs-CRP在妊娠期糖尿病肾病中的诊断价值分析

Diagnostic value of serum homocysteine combined with hs-CRP in gestational diabetic nephropathy

目的 :研究血清同型半胱氨酸联合hs-CRP在妊娠期糖尿病肾病中的诊断价值,为临床诊治提供参考。方法 :选择2017年1月～2017年12月期间在我院接受诊治的90例妊娠期糖尿病患者作为观察对象,依据有无肾功能损害分成单纯GDM组32例、早期DN组30例、临床DN组28例,另选择同期在我院接受产检的40例健康妊娠孕妇作为对照组。检测、观察四组孕妇的血清Hcy、hs-CRP水平,并对比分析血清Hcy、hs-CRP单组检测及联合检测的敏感性、特异性、准确性。结果 :单纯GDM组、早期DN组、临床DN组孕妇的血清Hcy、hs-CRP表达水平均高于对照组,且早期DN组、临床DN组高于单纯GDM组,临床DN组高于早期DN组,差异有统计学意义;血清Hcy、hs-CRP联合检测的敏感性、准确性均高于单独检测,差异有统计学意义;联合检测的特异性略高于单独检测,但差异无统计学意义。结论 :血清同型半胱氨酸联合hs-CRP在妊娠期糖尿病肾病中具有较高的诊断价值,其能使临床检测的敏感性、准确性提高,利于临床及早制定防治措施,值得临床推广。

Objective To study the diagnostic value of serum homocysteine combined with hs-CRP in gestational diabetic nephropathy and provide reference for clinical diagnosis and treatment.Methods 90 cases of gestational diabetes patients who were diagnosed and treated in our hospital from January 2017 to December 2017 were selected as the subjects of this study.According to the presence or absence of renal impairment,there were 32 cases in the GDM group,30 cases in the early DN group,and 28 cases in the clinical DN group.In the same period,40 healthy pregnant women who received the birth control in our hospital were selected as the control group.To observe and compare the serum levels of Hcy and hs-CRP in the four groups of pregnant women,and compare the sensitivity,specificity,and accuracy of serum Hcy and hs-CRP single-group detection and combined detection.Results The serum levels of Hcy and hs-CRP in pregnant women with GDM alone,early DN group,and clinical DN group were significantly higher than those in the control group.The early DN group and clinical DN group were higher than those in the simple GDM group,and the clinical DN group was higher than the early DN.In group,the difference was statistically significant;The sensitivity and accuracy of combined detection of serum Hcy and hs-CRP were higher than those of the single test,and the difference was statistically significant.The specificity of the combined detection was slightly higher than that of the single test,but the difference was not statistically significant.Conclusion Serum homocysteine combined with hs-CRP has a high diagnostic value in gestational diabetic nephropathy.It can improve the sensitivity and accuracy of clinical detection,and it is helpful for the early clinical development of prevention and treatment measures.It is worthy of clinical promotion.