保乳术治疗对乳腺癌患者疗效、血清肿瘤标志物的影响及预后分析

Effect of breast-conserving therapy on efficacy, serum tumor markers and prognosis in patients with breast cancer

目的 :探讨保乳术治疗对乳腺癌患者的疗效及血清肿瘤标志物的影响,并分析预后。方法 :收集2014年7月~2015年11月我院收治的100例拟进行手术的乳腺癌患者的临床资料,依据手术方式不同分为对照组和观察组,各50例。对照组患者给予改良根治术治疗,观察组患者接受保乳术治疗。比较两组患者血清标志物水平的变化、自尊度、生命质量评分及临床疗效。随访2年,比较两组患者生存率、复发率、转移率及并发症发生率。结果 :两组患者术前的血清肿瘤标志物差异均无统计学意义;术后4w,两组患者CA15-3、CEA、TPA和TSGF均显著低于术前,但两组术后上述各指标比较不具有统计学意义。两组间总有效率、疾病控制率、1年生存率、2年生存率、局部复发率及远处转移率比较无统计学意义。观察组患者自尊评分、生命质量评分均优于对照组,并发症发生率低于对照组。结论 :保乳手术效果优于改良根治术,有效减少并发症的发生,提高生活质量,一定程度上可缓解患者心理的各种不适,同时对患者血清肿瘤标志物改善无不良影响。

Objective To investigate the effect of breast-conserving therapy on breast cancer patients and serum tumor markers,and to analyze the prognosis.Methods The clinical data of 100 patients with breast cancer who were going to undergo surgery from July 2014 to November 2015 were collected.The clinical data were divided into control group and observation group according to different surgical methods,50 cases each.The control group received modified radical mastectomy and the observation group received breast-conserving surgery.The control group received modified radical mastectomy and the observation group received breast-conserving surgery.Changes in serum marker levels,self-esteem,quality of life scores,and clinical outcomes were compared between the two groups.After 2 years of follow-up,the survival rate,recurrence rate,metastasis rate and complication rate of the two groups were compared.Result There were no significant differences in serum tumor markers between the two groups.At 4 weeks after operation,the levels of CA15-3,CEA,TPA and TSGF were significantly lower in the two groups than before surgery,but the above indexes were not statistically significant.There was no significant difference in total effective rate,control rate,1-year survival rate,2-year survival rate,local recurrence rate and distant metastasis rate between the two groups.The self-esteem score and quality of life score of the observation group were better than the control group,and the complication rate was lower than that of the control group.Conclusion The effect of breast-conserving surgery is better than that of modified radical mastectomy,which can effectively reduce the occurrence of complications and improve the quality of life.It can alleviate the psychological discomfort of patients to a certain extent,,and has no adverse effects on the improvement of serum tumor markers.