河南省100例健康成人外周血淋巴细胞微核测定

Micronucleus test in peripheral lymphocytes of 100 healthy adults in Henan province

本文报道河南省100例健康成人外周血淋巴细胞微核检查结果;同时对不同性别,不同年龄及食管癌高、低发区健康成人的微核出现率进行了比较。结果100例健康人外周血微核淋巴细胞出现率为42%,淋巴细胞微核出现率为0.61%,微核淋巴细胞中多微核淋巴细胞出现率为11.44%;男女性别间微核淋巴细胞出现率,淋巴细胞微核出现率及微核淋巴细胞中多微核淋巴细胞出现率均无统计学差异;随着年龄增大,微核淋巴细胞出现率及淋巴细胞微核出现率均增高;食管癌高发区组微核淋巴细胞出现率和淋巴细胞微核出现率均高于低发区组(P<0.01)。结果表明,要确定健康成人外周血淋巴细胞微核出现率时,应考虑年龄及不同地区的环境影响。

This article presents the results of micronucleus test in peripheral lymp-hocytes of 100 healthy adults in Henan Province and the comparison of theincidence of micronuclei between individuals of different sexes and ages, livi-ng in the areas of low and high incidences of esophageal cancer. The incide-nce of micronucleated lymphocytes of the peripheral blood was 42%; the inc-idence of micronuclei in lymphocytes was 0.61%; the incidence of multi-mic-ronuclei in the micronucleated lymphocytes was 11.48%. Between the twosexes there was no significant statistical difference in the incidences of mi-cronucleated lymphocytes, micronuclei in lymphocytes and the multi-micron-ucleated lymphocytes. The incidences of micronucleated lymphocytes and mic-ronuclei in lymphocytes increased with age. The incidences of micronucle atedlymphocytes and micronuclei in lymphocytes of those in the high risk areawere higher than those of the people living in low risk area (P<0.01).The results indicate that the effects of aeg and geographic factors should betaken into consideration if the incidences of micronuclei in lymphocytes of the peripheral blood of healthy adults are to be determined.