术前预后营养指数对贲门腺癌患者术后预后评价的价值

Effects of prognostic nutritional index on postoperation prognosis of patients with gastric cardia adenocarcinoma

目的:研究术前预后营养指数(PNI)对贲门腺癌(GCA)术后预后的评价价值。方法:回顾性分析河南省安阳市肿瘤医院接受根治术治疗的GCA患者627例的临床资料。根据术前1周内检查的血清白蛋白水平和淋巴细胞数计算PNI。结果:PNI判定术后5 a生存的ROC曲线下面积为0. 650,最佳截断值为45. 5; PNI≥45. 5者375例,<45. 5者252例。Cox回归结果显示,PNI <45. 5是GCA患者术后预后的独立危险因素,HR(95%CI)为2. 645(2. 183～3. 205)。结论:术前PNI可用于GCA患者术后预后的判定,PNI≥45. 5的患者预后相对较好。

Aim:To explore the value of prognostic nutritional index(PNI)for assessing postoperation prognosis of the patients with gastric cardia adenocarcinoma(GCA).Methods:The data of 627 patients with GCA treated by radical resection from Anyang tumor hospital in Henan Province,were retrospectively analyzed.PNI was calculated based on the level of albumin and the number of lymphocytes during the first week before surgery.Results:The area under the curve of the ROC of PNI for diagnosis of GCA postoperation prognosis was 0.650,the optimal cut-off value was 45.5,and there were 375 patients with PNI≥45.5 and 252 patients with PNI<45.5.The results of Cox regression showed that PNI<45.5 were independent factor affecting the prognosis of GCA patients,and HR(95%CI)was 2.645(2.183-3.205).Conclusion:Preoperative PNI is associated with postoperative prognosis of patients with GCA,and the prognosis of patients with PNI≥45.5 may be relatively good.