脑胶质母细胞瘤切除术中脑室开放的影响因素及预后分析

Analysis of related factors of ventricular opening in glioblastoma and its influence on prognosis

目的:探讨人脑胶质母细胞瘤(GBM)切除术中脑室开放的相关因素及其对预后的影响。方法:收集519例接受原发性GBM切除的患者资料,按术中是否进行脑室开放进行分组,回顾性分析与脑室开放相关因素,用Kaplan-Meier生存曲线法估计两组的生存率,并用log-rank检验进行生存率的比较。利用Cox比例风险回归模型对其他相关因素进行校正,评价脑室开放对手术预后的影响。结果:519例患者中212例术中开放了脑室。多因素logistic回归分析结果显示,次全切除和脑室粘连的患者更倾向于术中开放脑室(P <0. 05)。生存分析显示,两组的中位生存期分别为12. 1和15. 7个月,差异无统计学意义(P=0. 152)。结论:GBM切除术中脑室开放是安全的。

Aim:To analysis the related factors of ventricular opening in glioblastoma(GBM)and its influence on prognosis.Methods:A total of 519 patients who underwent primary GBM resection were collected and grouped according to whether the ventricle was open or not during surgery.Retrospective analysis of individual and clinical factors associated with ventricular openness was made.The Kaplan-Meier survival curve was used to estimate the survival rate of the two groups,and the survival rate was compared by log-rank test.The Cox proportional hazards regression model was used to correct oth-er relevant factors in evaluating the impact of ventricular opening on surgical outcomes.Results:Among 519 patients,212 underwent intraoperative ventricular opening.Multivariate logistic regression showed that patients with subtotal resection and ventricular adhesion were more likely to have open ventricles(P<0.05).The medium survival of the two groups was12.1 and 15.7 months(P=0.152).Conclusion:Ventricular opening is considerable safe during GBM resection.