女性食管癌患者临床病理特征和预后因素分析

Clinicopathological characteristics and survival analysis of female patients with esophageal carcinoma

目的探讨女性食管癌患者的临床病理特征及预后影响因素。方法回顾性分析2009年1月至2013年12月在河南省肿瘤医院住院且经手术病理证实为食管癌的851例女性患者的临床病理资料及生存资料,并与同期的1 873例男性食管癌患者进行对比分析。采用K-M单因素分析和COX回归多因素分析方法分析影响女性食管癌患者预后的因素。结果女性食管癌患者与男性食管癌患者在发病年龄、肿瘤位置、病变长度及浸润深度、TNM分期方面比较,差异有统计学意义(P<0.05)。男、女患者1、3、5年累计生存率分别为86%、59%、42%和89%、65%、48%,两者生存期差异有统计学意义(P<0.05)。肿瘤长度、浸润深度、TNM分期是女性食管癌患者的独立预后因素。结论女性食管癌的病理特点、生存预后与男性患者各有不同。女性食管癌患者的预后要优于男性,可能与其有不同的病理特点有关。

Objective To study the clinicalopathological characteristics of female patients with esophageal cancer and prognostic factors of survival. Methods The clinical data of 851 female patients with esophageal cancer from January of 2009 to December of 2013 in Affiliated Tumor Hospital of Zhengzhou University were retrospective analyzed and compared with 1 873 male patients with esophageal cancer. The K- M analysis and COX regression analysis method were used to analyze the prognostic factors of female patients with esophageal cancer. Results There were statistical differences in the onset age,tumor location,the lesion length and infiltration depth and TNM staging between female patients and male patients with esophageal cancer( P <0. 05). 1,3,5- year survival rates of Male and female patients were 86%,59%,42% and 86%,65%,48% respectively,and the differences were statistically significant( P < 0. 05). Tumor length,infiltration depth,TNM stage were independent prognostic factors for female patients with esophageal cancer. Conclusion The pathological characteristics and the prognosis of female patiants with esophageal cancer were different from male patients with esophageal cancer. The prognosis of female patients with esophageal cancer is better than male patients,and it may be associated with different pathological characteristics.