核因子-κB及其在气道炎症中作用研究进展

Progress of nuclear factor-kappa B and its role in airway inflammation

核因子-κB是一种在基因转录水平发挥调节功能的蛋白质家族。核因子-κB与细胞核内相关DNA广谱基因启动子序列结合,可参与调控炎性因子、趋化因子、细胞黏附分子、生长因子等表达,在炎症反应、自身免疫反应、细胞增殖与凋亡及肿瘤的发生发展等方面均发挥重要作用,同时核因子-κB与过敏性哮喘、过敏性鼻炎等气道炎症疾病的发生发展密切相关。本文就核因子-κB及其在气道炎症中作用的研究进展作一综述。

Nuclear factor-kappa B is a protein family which plays a regulatory function in the level of gene transcription.Nuclear factor-kappa B participates in the regulation of inflammatory cytokines,chemokines,cell adhesion molecules,growth factors and so on by binding to the nuclear associated DNA broad spectrum gene promoter sequence.It not only plays an important role in the inflammatory response,autoimmune reaction,cell proliferation and apoptosis,and the occurrence and development of tumor,but also is closely correlated with the occurrence and development of airway inflammatory diseases,such as allergic asthma,allergic rhinitis and the others.This paper reviews the function of nuclear factor-kappa B and its role in airway inflammation.