摘要
间充质干细胞是一种来源广泛的具有多向分化潜能的细胞,其中来自于脐带华通胶的间充质干细胞即脐带间充质干细胞(human umbilical cord-derived mesenchymal stem cells,hUC-MSCs),由于hUC-MSCs具有易获得、潜能性广、易扩增、免疫原性低、伦理争议小等优点,是干细胞治疗中一种具有优势的选择。有研究证实其具有抗肿瘤特性,但也有部分研究得出相矛盾的结果,hUC-MSCs对肿瘤的作用机制仍有待于进一步研究。本文就hUC-MSCs的优势、免疫特性、肿瘤作用机制及其安全性的研究进展作一综述。
Mesenchymal stem cells,from various tissues,have the potential of multi-directional differentiation.mesenchymal stem cells derived from Wharton's jelly,termed as human umbilical cord-derived mesenchymal stem cells,is a prominent choice for stem cell based therapy because of the advantages of easy harvest,wide potency,easy amplification,low immunogenicity and ethical access.Some researchers have confirmed the efficiency of anti-tumor,but controversial results also exist.The explicit underlying mechanism needs to be investigated further.This paper reviews the research progress of the advantages,immune features,anti-tumor mechanisms and safety of human umbilical cord-derived mesenchymal stem cells.
出处
《中华实用诊断与治疗杂志》
2017年第4期403-406,共4页
Journal of Chinese Practical Diagnosis and Therapy
基金
河南省医学科技攻关计划项目(201301007)
关键词
脐带间充质干细胞
优势
抗肿瘤机制
安全性
Human umbilical cord-derived mesenchymal stem cells
advantages
anti-tumor mechanism
safety
