摘要
目的探讨药物流产后应用短效避孕药屈螺酮炔雌醇片的临床价值。方法早孕要求药物流产患者171例,流产后服用屈螺酮炔雌醇片86例为观察组,不服用屈螺酮炔雌醇片85例为对照组。对照组药物流产给予米非司酮+米索前列醇口服,观察组药物流产方法同对照组,并在绒毛排出后口服屈螺酮炔雌醇片,连续3个月经周期。比较2组药物流产后阴道流血时间,行清宫术比率,第4次月经来潮前子宫内膜厚度,药物流产6个月内月经紊乱(包括周期延长或缩短、闭经)及盆腔感染发生率。结果观察组阴道流血时间[(8.25±5.48)d]较对照组[(14.23±8.57)d]明显缩短(P<0.05);观察组行清宫术比率(1.16%)、药物流产6个月内月经紊乱及盆腔感染发生率(1.16%、1.16%、1.16%)低于对照组(15.29%、9.41%、5.88%)(P<0.05);观察组流产后第4次月经来潮前子宫内膜厚度[(9.30±1.15)mm]与对照组[(10.50±1.83)mm]比较差异无统计学意义(P>0.05)。结论药物流产后及时服用短效口服避孕药屈螺酮炔雌醇片可缩短阴道流血时间,降低药物流产后清宫术比率,减少盆腔感染和月经紊乱。
Objective To study the clinical significance of drospirenone-ethinylestradiol(DE)after medical abortion.Methods A total of 171 pregnant women willing for medical abortion were divided into observation group receiving DE(n=86)and control group not receiving DE(n=85).Control group was given oral administration of mifepristone and misoprostol.Observation group was given oral administration of DE after villus discharge for 3 menstrual cycles besides the treatment in control group.The duration of vaginal bleeding,endometrial thickness,curettage rate,endometrial thickness before the 4th menstrual,incidence of menstrual disorders in 6 months including amenorrhea and cycle lengthening or shortening,and pelvic infection rate were compared between two groups.Results The vaginal bleeding duration was significant shorter in observation group((8.25±5.48)d)than that in control group((14.23±8.57)d)(P<0.05).The curettage rate(1.16%),and the incidences of menstrual disorder(1.16%)and pelvic infection(1.16%)in 6 months in observation group were significantly lower than those in control group(15.29%,9.41%,5.88%)(P<0.05).There was no significant difference in the endometrial thickness between observation group((9.30±1.15)mm)and control group((10.50±1.83)mm)before the 4th menstrual(P>0.05).Conclusion Oral administration of DE after medical abortion can shorten the duration of vaginal bleeding,reduce the curettage rate,and reduce pelvic infection and menstrual disorders.
出处
《中华实用诊断与治疗杂志》
2017年第5期493-495,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
河南省计划生育委员会科技计划一般项目(2011019)
关键词
药物流产
屈螺酮炔雌醇片
清宫术
盆腔感染
月经紊乱
Medical abortion
drospirenone-ethinylestradiol
uterine curettage
pelvic infection
menstrual disorders