巨噬细胞诱导肾间质纤维化机制研究进展

Progress of macrophages induced renal interstitial fibrosis

肾间质纤维化是指胶原分子在肾间质的累积,是慢性肾脏病的最终病理结局和共同死亡通路。肾间质纤维化发生、发展涉及多种细胞及分子,包括巨噬细胞、肌成纤维细胞、生长因子、基质金属蛋白酶或基质金属蛋白酶抑制物等。巨噬细胞在肾间质纤维化的进程中起重要作用,巨噬细胞的异质性可促进肾纤维化,且对肾脏损伤修复有重要作用。M1型活化巨噬细胞有促炎及促纤维化的作用,M2型活化巨噬细胞可能发挥抗纤维化及促进组织修复作用。本文就巨噬细胞诱导肾间质纤维化机制的研究进展作一综述。

Renal interstitial fibrosis(RIF),accumulation of collagen molecule in renal interstitium,is an eventual pathological outcome and common lethal pathway of chronic renal disease.The development of RIF is involved in many cellular and molecular mediators including macrophages,myofibroblasts,growth factors,matrix metalloproteinases and tissue inhibitor of metalloproteinases.Heterogeneity of macrophages could promote renal fibrosis and plays an important role in the repair of renal injury.M1 phenotype macrophages promote tissue inflammation and fibrosis,however M2 phenotype macrophages may play an anti-fibrotic function and promote tissue repair.This paper reviews the research progress of the mechanism of macrophages induced RIF.