摘要
目的探讨新生儿黏质沙雷菌感染的敏感药物和治疗方案。方法回顾性分析9例NICU中感染黏质沙雷菌新生儿的临床资料。结果共分离17株黏质沙雷菌,17株黏质沙雷菌均对美罗培南、头孢哌酮舒巴坦等药物敏感,最小抑菌浓度值≤1;9例患儿中1例使用头孢哌酮/舒巴坦进行治疗,8例使用美罗培南进行治疗;4例治愈,2例遗留后遗症,3例死亡。结论新生儿黏质沙雷菌感染可采用美罗培南、头孢哌酮舒巴坦等敏感抗生素治疗,美罗培南对其导致的脓毒血症有明显疗效。
Objective To explore the sensitizing drugs and treatment scheme of Serratia marcescens(Sm)infections in neonates.Methods The clinical data of 9neonates with Sm infections in NICU were retrospectively analyzed.Results There were 17 strains of Sm separated,which were all sensitive to meropenem,cefoperazone sulbactam and other drugs.The minimal inhibitory concentration value was 1or less.In 9neonates,1was treated with cefoperazone suibactam and 8were treated with meropenem.Four neonates were cured,2had sequelae,and 3died.Conclusion Meropenem and cefoperazone suibactam could be used as sensitizing drugs for Sm infection,and meropenem could effectively treat sepsis induced by Sm.
出处
《中华实用诊断与治疗杂志》
2017年第8期782-783,共2页
Journal of Chinese Practical Diagnosis and Therapy
基金
河南省科技攻关项目(122102310602)
关键词
黏质沙雷菌
医院感染
美罗培南
Serratia marcescens
nosocomial infection
meropenem
