整合素α_3及β-catenin在胃癌中表达及临床意义

Expressions and clinical significances of integrin α_3 and β-catenin in gastric cancer

目的探讨整合素α_3和β-catenin在胃癌中表达情况及临床意义。方法取48例胃癌患者胃癌原发灶组织(胃癌组)和癌旁正常胃组织(对照组),采用免疫组织化学法检测2组integrinα_3和β-catenin阳性表达率,比较胃癌组有无淋巴结转移、是否穿透浆膜、不同分化程度患者integrinα_3和β-catenin阳性表达率;分析胃癌组织中integrinα_3与β-catenin表达的相关性。结果胃癌组integrinα_3和β-catenin阳性表达率(43.75%、52.08%)明显高于对照组(6.25%、0)(P<0.05);胃癌组有淋巴结转移者integrinα_3和β-catenin阳性表达率(60.00%、64.00%)高于无淋巴结转移者(26.08%、39.13%)(P<0.05);穿透浆膜者(61.54%、65.38%)明显高于未穿透浆膜者(22.73%、36.36%)(P<0.05);低分化者(47.83%、56.52%)与中高分化者(40.00%、48.00%)比较差异无统计学意义(P>0.05);胃癌组integrinα_3表达与β-catenin呈正相关(r=0.360,P=0.016)。结论 integrinα_3和β-catenin在胃癌中异常高表达,二者可能协同参与胃癌的发生、侵袭及转移。

Objective To investigate the expressions and significances of integrin α_3 and β-catenin proteins in gastric cancer.Methods The expressions of integrin α_3 and β-catenin proteins were detected by immunohistochemical method in primary gastric cancer tissues(gastric cancer group)and adjacent normal tissues(control group)from 48 patients with gastric cancer to compare the positive rates of integrin α_3 and β-catenin proteins between those with and without lymph node metastasis,with and without serous infiltration,and between differently differentiated types in gastric cancer group.The correlation between integrin α_3 and β-catenin proteins was analyzed in gastric cancer group.Results The positive rates of integrinα3 andβ-catenin were significantly higher in gastric cancer group(43.75%,52.08%)than those in control group(6.25%,0)(P<0.05),in those with lymph node metastasis(60%,64%)than those without lymph node metastasis(26.08%,39.13%)(P<0.05),and in those with serous infiltration(61.54%,65.38%)than those without serous infiltration(22.73%,36.36%)(P< 0.05),and there were no significant differences between poorly differentiated type(47.83%,56.52%)and moderately and highly differentiated type(40.00%,48.00%)(P>0.05).The expression of integrin α_3 was positively correlated withβ-catenin(r=0.360,P=0.016)in gastric cancer group.Conclusion Both integrin α_3 and β-catenin are highly expressed in gastric cancer tissue,playing a synergic role in the development,invasion and metastasis.