胰岛β细胞自噬及其在糖尿病发病机制中作用研究进展

Islet β-cell autophagy and its role in the pathogenesis of diabetes mellitus

糖尿病的发生与胰岛素分泌异常密切相关,以胰岛素抵抗与胰岛β细胞功能紊乱为特点。自噬是溶酶体对细胞组分的分解代谢过程,在维持胰岛β细胞结构功能及内环境稳定上起重要作用,可改善炎症、氧化应激等对胰岛β细胞的损伤,延缓糖尿病的病程。本文就胰岛β细胞自噬及自噬在糖尿病代谢和发病机制中作用的研究进展作一综述。

The development of diabetes mellitus is closely correlated with abnormal insulin secretion,characterized by insulin resistance and isletβ-cell dysfunction.Autophagy is a process of catabolism of cellular components by lysosomes,playing an important role in maintaining β-cell structure and function and internal environment stability,which can protect the pancreatic islet β-cell from damage and delay the course of diabetes mellitus.This paper reviews the research progress of pancreatic β-cell autophagy and the role of autophagy in the pathogenesis of diabetes mellitus.