血脂异常与IgA肾病患者临床病理关系及对预后影响的研究进展

Relationship of dyslipidemia with clinicopathological features and its influence on prognosis in patients with IgA nephropathy

IgA肾病是以系膜区免疫复合物IgA沉积为特点的系膜增生性肾小球肾炎,其临床表现多变,病理表现各异,主要由肾活检组织病理检查确诊,是导致终末期肾脏病的主要原发性疾病。血脂异常既是动脉粥样硬化、冠心病和高血压等心血管疾病发生、发展的危险因素,也是慢性肾脏病伴随的临床表现,可加快肾脏疾病进展。血脂异常与IgA肾病的进展和预后相关,但血脂变化与IgA肾病临床表现、病理改变的关系尚不明确。本文就血脂异常与IgA肾病临床病理的关系及其对预后影响的研究进展作一综述。

IgA nephropathy,mesangial proliferative glomerulonephritis characterized by mesangial immune complexes IgA deposition,has various clinical manifestations and different pathological manifestations.Its diagnosis mainly depends on renal biopsy,and it is a main primary disease leading to end-stage renal disease in China.In recent years,it shows a gradually increasing trend.Dyslipidemia is a risk factor for atherosclerosis,coronary heart disease and hypertension,as well as a clinical manifestation associated with chronic kidney disease,which could accelerate the progress of kidney disease.Dyslipidemia is correlated with the progress and prognosis of IgA nephropathy,but the relationship of the change of blood lipid with the clinical and pathological manifestations of IgA nephropathy is not clear.This paper reviews the relationship of dyslipidemia with clinical and pathological features of IgA nephropathy and the influence of dyslipidemia on the prognosis.