摘要
Krüppel样因子(Krüppel-like factors, KLFs)是一组保守、含有锌指结构的转录因子,通过转录调控靶基因表达,参与细胞增殖、分化和凋亡以及肿瘤的发生、发展。近年来,KLFs与胰腺癌的关系成为研究的热点。本文就KLFs主要成员与胰腺癌转移关系的研究进展作一综述。
Krüppel-like factors(KLFs)family is a conserved transcription factor family containing zinc finger domain,and widely involved in cell proliferation,differentiation and apoptosis,as well as tumor development and progression via the transcriptional regulation of target gene expression.Recently,more and more studies start to focus on the relationship between KLFs and pancreatic cancer.This paper reviews the relationship between major KLFs and the metastasis of pancreatic cancer.
作者
陈彦飞
姚俊
杨俊强
李文耀
CHEN Yanfei;YAO Jun;YANG Junqiang;LI Wenyao(Grade 2016,Henan University of Science and Technology,Luoyang 471000,China;Department of Oncology,the First Affiliated Hospital of Henan University of Science and Technology,Cancer Institute of Henan University of Science and Technology,Henan Key Laboratory of Cancer Epigenetics,Luoyang 471003,China)
出处
《中华实用诊断与治疗杂志》
2019年第5期512-514,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
国家自然科学基金(U1204819)
