导痰祛瘀汤治疗糖尿病合并冠心病临床研究

Clinical Study of TCM Daotan Quyu Decoction in Treatment of Diabetes with Coronary Heart Disease

目的:探讨导痰祛瘀汤辅助治疗糖尿病合并冠状动脉粥样硬化性心脏病(简称冠心病)的临床疗效。方法:将120例糖尿病合并冠心病患者随机分为两组。对照组接受常规治疗,观察组在对照组基础上联用导痰祛瘀汤。对比两组治疗前后糖尿病相关指标、血清脂联素、超敏C反应蛋白、血流变指标及总体疗效。结果:1两组治疗后空腹血糖、餐后2小时血糖、糖化血红蛋白较治疗前均明显下降(P<0.05);两组治疗后胰岛素抵抗指数、血清超敏C反应蛋白较治疗前均明显下降(P<0.05),且观察组明显优于对照组,差异有统计学意义(P<0.05);两组治疗后血清脂联素水平明显上升(P<0.05),且观察组明显高于对照组,差异有统计学意义(P<0.05)。2两组治疗后全血低切黏度、高切黏度、血浆黏度均明显下降,且观察组治疗后明显低于对照组,差异有统计学意义(P<0.05)。3观察组有效率明显高于对照组,差异有统计学意义(P<0.05)。结论:导痰祛瘀汤治疗糖尿病合并冠心病临床疗效显著。

Objective:To investigate the clinical curative efficacy of TCM Daotan Quyu Decoction in treatment of Diabetic with Coronary Heart Disease.Methods:120 cases of patients were randomly divided into control group and observation group.The control group received routine treatment,while the observation group received TCM treatment Daotan Quyu Decoction in addition to that of the control group.The levels of serum adiponectin,high sensitivity C-reactive protein,hemorheological indexes and overall curative effect were compared between the two groups before and after treatment.Results:After treatment,the levels of fasting blood glucose,2 hours postprandial blood glucose and HbA 1c decreased significantly(P < 0.05).After treatment,the levels of hs-CRP and serum hs-CRP of the two groups significantly decreased(P < 0.05).The serum adiponectin levels of the two groups was significantly higher than that before treatment(P < 0.05).There were significantly differences between the both groups in the above mentioned indicators,with the observation group being better(P < 0.05).(2) The low shear viscosity,high shear viscosity and plasma viscosity of the two groups were significantly lowered than those of the control group after treatment(P < 0.05).(3) The effective rate of the observation group was significantly higher than that of the control group(P < 0.05).Conclusion:Daotan Quyu Decoction is effective in treatment of Diabetes with Coronary Heart Disease.