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健脾祛湿补肾法对非肥胖型多囊卵巢综合征患者卵巢功能的保护作用 被引量:9

Protective Effect of Invigorating Spleen,Removing Dampness and Tonifying Kidney Therapy on Ovarian Function in Non-obese PCOS Patients
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摘要 目的:观察健脾祛湿补肾法治疗非肥胖型多囊卵巢综合征(polycystic ovary syndrome,PCOS)的价值,分析该方法对患者卵巢功能的保护作用。方法:86例非肥胖型PCOS患者根据随机数字表,将患者分为对照组与治疗组,各43例。对照组给予达英-35,治疗组在对照组治疗基础上给予健脾祛湿补肾法,治疗期间记录不良反应发生情况。连续治疗3个月后停止用药并随访3个月,治疗结束时比较两组患者临床疗效;分别于治疗前、治疗第1个月、治疗结束时,比较两组患者卵巢储备相关激素水平:抗苗勒管激素(anti-mullerian hormone,AMH)、抑制素B(inhibin B,INHB)水平;分别于治疗前、治疗结束时及治疗后第3个月观察并比较两组患者卵泡发育情况(包括卵巢体积及排卵率)。结果:治疗组有效率为83.72%,对照组为62.79%,两组有效率比较,差异有统计学意义(P<0.05)。两组患者治疗第1个月、治疗结束时AMH、INHB水平均低于治疗前,且治疗组各时点AMH、INHB水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后第3个月左右两侧卵巢体积小于对照组,排卵率高于对照组,差异均有统计学意义(P<0.05)。结论:健脾祛湿补肾法治疗非肥胖型PCOS疗效确切,可改善患者卵巢功能,提高其卵泡发育质量,促进排卵,且不会增加用药不良反应。 Objective:To observe the value of invigorating spleen,removing dampness and tonifying kidney therapy in the treatment of non-obese polycystic ovary syndrome(PCOS),and to analyze the protective effect of this method on ovarian function of patients.Methods:86 non-obese PCOS patients were divided into control group and treatment group according to random number table,43 cases in each group.The control group was given Diane-35,while the treatment group was invigorating spleen,removing dampness and tonifying kidney therapy on the basis of the treatment of the control group.The occurrence of adverse reactions was recorded during the treatment.After 3 months of continuous treatment,the drug was discontinued and followed up for 3 months.At the end of treatment,the clinical efficacy of the two groups was compared.The levels of ovarian reserve-related hormones:anti-Mullerian hormone(AMH)and inhibin B(INHB)were compared before treatment,at the end of the first month of treatment and at the end of treatment.The follicular development(including ovarian volume and ovulation rate)of the two groups were observed and compared before treatment,at the end of treatment and at the third month after treatment.Results:The effective rate was 83.72%in the treatment group and 62.79%in the control group.There was significant difference between the two groups(P<0.05).The levels of AMH and INHB in the first month of treatment and at the end of treatment were lower than those before treatment,and the levels of AMH and INHB in the treatment group were lower than those in the control group at all time points,and the difference was statistically significant(P<0.05).About 3 months after treatment,the ovarian volume of both sides was smaller than that of the control group,and the ovulation rate was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:The method of invigorating spleen,removing dampness and tonifying kidney therapy is effective in treating non-obesity PCOS.It can improve ovarian function,follicular development quality and ovulation without increasing adverse drug reactions.
作者 李潇 张宇航 周艳艳 LI Xiao;ZHANG Yuhang;ZHOU Yanyan(The Second Affiliated Hospital to Henan University of Chinese Medicine,Zhengzhou Henan China 450002;Henan University of Chinese Medicine,Zhengzhou Henan China 450046)
出处 《中医学报》 CAS 2019年第9期1977-1981,共5页 Acta Chinese Medicine
基金 2017年河南省中医药管理局资助项目(2017ZY-2017)
关键词 非肥胖型多囊卵巢综合征 健脾祛湿补肾法 卵巢功能 达英-35 中西医结合 non-obese polycystic ovary syndrome invigorating spleen,removing dampness and tonifying kidney therapy ovarian function Diane-35 integration of traditional and western medicine
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