改良电针仪治疗失神经肌肉的安全性及有效性研究

Clinical effect and safety of modified electroacupuncture device in treatment of denervated muscle

目的:探讨改良电针仪(专利号:ZL. 2015 2 0812858. 8)治疗失神经肌肉的安全性及有效性。方法:将雄性SD大鼠随机分为对照组及电针组,行坐骨神经钳夹伤模型制备,对坐骨神经损伤大鼠进行电针治疗,观察实验大鼠腓肠肌恢复率及电针部位肌肉病理改变。结果:电针10d组极少量结缔组织增生,其余未出现明显改变。电针30d组出现炎症反应,仅1只实验大鼠表现为重度,其余均表现为轻度或轻微,说明改良电针治疗仪不会对肌肉组织造成电损伤;电针组治疗10d后腓肠肌恢复率偏低,治疗30d后恢复率升高,且与对照组相比差异有统计学意义(P <0. 05)。结论:改良电针可以延缓失神经肌肉的萎缩,且不会对肌肉组织造成电解损伤。

Objective: To investigate the clinical effect and safety of a modified electroacupuncture device( patent number: ZL. 2015 2 0812858. 8) in the treatment of denervated muscle. Methods: Male Sprague-Dawley rats were randomly divided into control group and electroacupuncture group. Sciatic nerve clamping was performed to establish a rat model of denervated muscle. The rats with sciatic nerve injury were treated with electroacupuncture,and the experimental rats were observed in terms of gastrocnemius recovery rate and pathological change of the muscle under electroacupuncture. Results: The 10-day electroacupuncture group had slight connective tissue hyperplasia,and there were no marked changes in the other groups. The 30-day electroacupuncture group had inflammatory response,with severe inflammatory response in one rat and mild or slight inflammatory response in the other rats,suggesting that the modified electroacupuncture device did not cause electrical injury to muscle tissue. Compared with the control group,the electroacupuncture group had a significantly lower gastrocnemius recovery rate after 10 days of treatment and a significant increase in gastrocnemius recovery rate after 30 days of treatment( P < 0. 05). Conclusion: The modified electroacupuncture device can delay the atrophy of denervated muscle and does not cause electrical injury to muscle tissue.