银杏叶提取物对雌性小鼠刻板、焦虑及记忆行为的影响

Effect of ginkgo biloba extract on stereotyped,anxiety-like,and memory behaviors in female mice

目的:探讨银杏叶提取物(GBE)对老龄雌性小鼠刻板、焦虑及记忆行为能力的影响。方法:选取7月龄的C57BL/6J雌性小鼠13只,将其随机分为实验组与对照组,实验组以银杏叶提取物灌胃,对照组以蒸馏水灌胃,2组均干预10d。给药期间每天测量体质量,给药结束后进行自我梳理、明暗箱和旷场电刺激等行为学测试。结果:与对照组相比,实验组小鼠体质量无显著变化,自我梳理次数显著降低,焦虑行为无显著变化,电击后静止时间显著延长。结论:GBE可降低老龄雌性小鼠的刻板行为,且对其学习记忆有一定改善作用,提示银杏叶有效成分对神经精神疾病可能有一定的治疗作用。

Objective:To investigate the effect of ginkgo biloba extract(GBE)on stereotyped,anxiety-like,and memory behaviors in elderly female mice.Methods:A total of 13 C57 BL/6 J mice aged 7 months were randomly divided into experimental group and control group.The mice in the experimental group were given GBE by gavage,and those in the control group were given distilled water by gavage.The course of treatment was 10 days for both groups.Body weight was measured every day during administration,and related behavioral tests were performed,including self-grooming,light/dark box,and open field test with electrical stimulation.Results:Compared with the control group,the experimental group had a significant reduction in the number of times of self-grooming and a significantly longer latency after electrical stimulation,with no significant changes in body weight or anxiety-like behavior.Conclusion:GBE can reduce stereotyped behavior and improve learning and memory in elderly female mice,suggesting that the effective constituents of ginkgo leaf may exert a certain therapeutic effect on neuropsychiatric diseases.