加味栝楼薤白汤治疗痰瘀互结型慢性稳定型心绞痛30例

Clinical effect of Jiawei Kuolou Xiebai decoction in treatment of chronic stable angina with the syndrome of intermingled phlegm and blood stasis: An analysis of 30 cases

目的:观察加味栝楼薤白汤治疗痰瘀互结型慢性稳定型心绞痛的临床疗效。方法:将60例痰瘀互结型慢性稳定型心绞痛患者随机分为治疗组和对照组,每组各30例。2组均予以口服阿司匹林肠溶片治疗,治疗组在此基础上加服加味栝楼薤白汤治疗,对照组在此基础上加服脑心清片治疗。比较2组患者中医证候积分、西雅图心绞痛量表积分、中医证候疗效与心绞痛疗效。结果:中医证候疗效、心绞痛疗效的总有效率治疗组分别90. 0%、86. 7%,对照组分别为73. 3%、66. 7%,2组比较,差异均有统计学意义(P <0. 05);2组患者中医证候积分、西雅图心绞痛量表积分治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P <0. 05)。结论:选用加味栝楼薤白汤治疗痰瘀互结型慢性稳定型心绞痛可有效缓解患者胸闷、胸痛、心悸、气短等症状,提高中医证候疗效和心绞痛疗效,并可有效改善躯体受限活动的程度,值得临床推广。

Objective:To investigate the clinical effect of Jiawei Kuolou Xiebai decoction in the treatment of chronic stable angina with the syndrome of intermingled phlegm and blood stasis.Methods:A total of 60 patients with chronic stable angina with the syndrome of intermingled phlegm and blood stasis were randomly divided into treatment group and control group,with 30 patients in each group.The patients in the control group were given oral aspirin enteric-coated tablets and Naoxinqing Tablets,and those in the treatment group were given oral aspirin enteric-coated tablets and Jiawei Kuolou Xiebai decoction.The two groups were compared in terms of traditional Chinese medicine(TCM)syndrome score,Seattle Angina Questionnaire score,outcome of TCM syndrome,and outcome of angina pectoris.Results:There were significant differences between the treatment group and the control group in the overall response rate of TCM syndrome(90.0%vs 73.3%,P<0.05)and angina pectoris(86.7%vs 66.7%,P<0.05).Both groups had significant changes in TCM syndrome score and Seattle Angina Questionnaire score after treatment,and there were significant differences in these scores between the two groups after treatment(P<0.05).Conclusion:For patients with chronic stable angina with the syndrome of intermingled phlegm and blood stasis,Jiawei Kuolou Xiebai decoction can effectively relieve the symptoms of chest distress,chest pain,palpitation,and short breath,improve the outcome of TCM syndrome and angina pectoris,and effectively improve the degree of limited physical activity.Therefore,it holds promise for clinical application.