加味半夏白术天麻汤对痰浊上扰型偏头痛患者的疗效及内皮素-1及一氧化氮水平的影响

The Correlation Study of Modified Banxia Baizhu Tianma Decoction on the Level of Endothelin-1 and Nitric Oxide of Migraine Patients with Upward Disturbance of Phlegm-Turbidity Syndrome

目的观察加味半夏白术天麻汤对痰浊上扰型偏头痛的临床疗效及对内皮素-1和一氧化氮水平的影响。方法90例痰浊上扰型偏头痛患者随机分为观察组(45例)和对照组(45例),观察组给予加味半夏白术天麻汤,对照组给予盐酸氟桂利嗪,监测两组偏头痛患者治疗前后头痛发作频次、头痛持续时间、疼痛程度及内皮素-1和一氧化氮水平,疗程6周后统计2组患者的临床疗效及相关指标的差异。结果观察组总有效率高于对照组(P<0.05),观察组和对照组治疗后两组患者的内皮素-1水平均较前有所下降(P<0.05),一氧化氮水平均较前有所升高(P<0.05)。观察组患者内皮素-1及一氧化氮水平较对照组改善明显(P<0.05)。结论加味半夏白术天麻汤辨证治疗痰浊上扰型偏头痛治疗有效,可能通过影响内皮素-1和一氧化氮水平起作用。

Objective To observe the effect of modified Banxia Baizhu Tianma decoction in treating migraine of type upward disturbance of phlegm-turbidity and on the level of endothelin-1 and nitric oxide. Methods A total of 90 patients with migraine of type upward disturbance of phlegm-turbidity were randomly divided into the observation group(n=45) which were treated by supplemented Banxia Baizhu Tianma Decoction and the control group(n =45) which were given flunarizine hydrochloride. The headache frequency, duration, the integration of degree and the levels of endothelin-1 and nitric oxide in the two groups were detected. After 6 weeks of treatmet, the differences of clinical effect and related indicators in both patients were calculated. Results The effective rate of observation group was obviously higher than the treatment group(P<0.05). The levels of endothelin-1 were decreased(P<0.05), while the nitric oxide were increased in both two groups after treatment(P <0.05). Compared with the control group, the levels of endothelin-1 and nitric oxide in observation group in observation group were improved(P<0.05). Conclusion The modified Banxia Baizhu Tianma decoction shows good effect on the migraine of type upward disturbance of phlegm-turbidity, which may be related with the levels of endothelin-1 and nitric oxide.