运动康复联合参附注射液对心肌病心衰大鼠血流动力学的影响

Effects of Exercise Rehabilitation and Shenfu Injection on Hemodynamics in Rats with Cardiomyopathy Heart Failure

目的观察运动康复联合参附注射液对心肌病所致心力衰竭大鼠血流动力学的影响。方法将50只SD雄性大鼠随机分为安静对照组(10只)与造模组(40只),造模组大鼠采用盐酸多柔比星腹腔注射7周造模,造模成功后的36只大鼠,按随机数字表法,分为模型组、参附组、运动康复组、运动康复参附组,每组9只。分别用生理盐水、参附注射液、运动康复、运动康复联合参附注射液干预4周,检测大鼠左室收缩压峰值(LVSP)、左舒张末压力(LVEDP)、左室等容收缩末期压力上升最大速度(+dp/dtmax)、左室压力下降最大速度(-dp/dtmax)等血流动力学指标。结果与模型组比较,参附组、运动康复组、运动康复参附组在LVSP、LVEDP、+dp/dtmax、-dp/dtmax差异有统计学意义(P<0.05);与运动康复参附组比较,参附组、运动康复组在LVSP、+dp/dtmax、-dp/dtmax差异有统计学意义(P<0.05);与运动康复参附组比较,参附组在LVEDP差异有统计学意义(P<0.05)。结论运动康复、参附注射液、运动康复联合参附注射液都能改善心衰大鼠血流动力学指标,提高心衰大鼠心脏功能,而运动康复联合参附注射液效果最好。

Objective To observe the effect of exercise rehabilitation combined with Shenfu injection on hemodynamics in rats with heart failure induced by cardiomyopathy. Methods 50 SD rats were randomly divided into the control group and model group, model group rats was injected doxorubicin hydrochloride intraperitoneally for 7 weeks, After successful modeling, the rats were divided into model group, Shenfu group, exercise group, exercise and Shenfu group according to the random number table method, 6 in each group. They will be treated with saline, Shenfu injection, exercise rehabilitation,exercise rehabilitation combined with Shenfu injection for 4 weeks. The hemodynamics parameters such as LVSP, LVEDP,+dp/dtmax,-dp/dtmax were measured. Results Compared with model group, there were significant differences in LVSP, LVEDP,+dp/dtmax and-dp/dtmax between Shenfu group, exercise group and exercise and Shenfu group(P<0.05). Compared with exercise and Shenfu group, there were significant differences in LVSP, +dp/dtmax and-dp/dtmax between Shenfu group and exercise group(P<0.05). Compared Shenfu group with exercise and Shenfu group, there was significant differences in LVEDP(P<0.05). Conclusion Exercise rehabilitation, Shenfu injection, exercise rehabilitation combined with Shenfu injection could improve the hemodynamic parameters and heart function of heart failure rats, but exercise rehabilitation combined with Shenfu injection is the best.