大承气汤佐治小儿肺炎伴高热的疗效及对自由基表达的影响

Effect of Dachengqi Decoction on Children with Pneumonia and High Fever and Its Influence on Free Radical Expression

目的探讨大承气汤治疗小儿肺炎伴高热的疗效及对自由基表达的影响。方法将肺炎患儿88例按照随机数字表法分为观察组和对照组,每组各44例,对照组患儿采用抗生素、抗病毒、退热镇咳的常规治疗,观察组患儿在常规治疗的基础上加用大承气汤治疗。比较两组患儿症状改善情况、治疗总有效率以及患儿治疗前后血清肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、超氧化物歧化酶(SOD)表达情况。结果观察组患儿症状改善(体温恢复、咳嗽停止、肺部湿啰音消失)用时均较对照组短,两组间差异具有统计学意义(P<0.01);观察组治疗总有效率(100%)高于对照组(88.64%),两组间差异具有统计学意义(P<0.05);与治疗前相比,两组患儿治疗后血清TNF-α、CRP表达水平均降低,SOD表达水平升高,差异具有统计学意义(P<0.01);且观察组改善优于对照组(P<0.01)。结论在常规治疗的基础上加用大承气汤疗效显著,可以有效降低小儿肺炎伴高热病例的自由基表达,减轻患儿炎症反应,促进患儿康复,值得在临床上推广使用。

Objective To investigate the curative effect of Dachengqi Decoction on children with pneumonia and high fever and its influence on free radical expression. Methods The 88 children with pneumonia were divided into observation group and control group according to random number table method, 44 cases in each group. The control group was treated with conventional treatment of antibiotics, antiviral and antipyretic antitussive. On the basis of conventional treatment, the observation group was treated with the decoction of Dachengqi decoction. The improvement of symptoms, the total effective rate and the serum TNF-α, C-reactive protein(CRP) and superoxide dismutase(SOD) expression of children before and after treatment were compared. Results The improvement time of symptoms(temperature recovery, cough, pulmonary rales) in observation group was shorter than that in the control group, the difference was statistically significant between the two groups(P<0.01). The total efficiency of the observation group(100%) was higher than the control group(88.64%), the difference between the two groups was statistically significant(P <0.05). Compared with before treatment, serum TNF-α, CRP expression levels decreased in two groups after treatment, the expression level of SOD increased, the differences were statistically significant(P<0.01);and the observation group was better than the control group(P<0.01).Conclusion On the basis of conventional treatment,Dachengqi decoction could effectively reduce the expression of free radicals in children with pneumonia and high fever,reduce the inflammatory reaction,promote the rehabilitation of children.It is worth promoting in clinic.