冠状动脉粥样硬化性心脏病患者经皮冠状动脉介入术后证候要素变化研究

The Research into Changes of Syndrome Elements in Patients with Coronary Heart Disease After Percutaneous Coronary Intervention

目的:观察冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)患者经皮冠状动脉介入术(percutaneous coronary intervention,PCI)术后证候要素的变化情况及变化规律。方法:对200例CHD患者进行证候要素辨证分型,比较PCI术前与术后1周、1个月、3个月、6个月证候要素分布情况。结果:CHD患者PCI术后不同时间点中医症候要素的变化规律是:术后1周:血瘀证>气虚证>痰浊证;术后1月、3个月:气虚证>血瘀者>痰浊证;术后6个月:血瘀证>气虚证>痰浊证。CHD患者PCI术前与术后1周、1个月、3个月证候要素分布情况比较,差异具有统计学意义(P<0.05)。CHD患者PCI术前与术后6个月证候要素分布情况比较,差异无统计学意义(P>0.05)。结论:CHD患者PCI术后患者证候要素的转化可能始于术后1周,在术后3个月、6个月时证候要素与术前之间的差异逐渐减小。

Objective:To observe the changes and rules of syndrome elements in patients with coronary heart disease(CHD) after percutaneous coronary intervention(PCI).Methods:Two hundred patients with CHD were classified according to syndrome elements.The distribution of syndrome elements before and after PCI was compared between one week,one month,three months and six months.Results:The changes of TCM syndrome elements in CHD patients at different time points after PCI were as follows:blood stasis syndrome > qi deficiency syndrome>phlegm turbidity syndrome one week after PCI.One month and three months after operation:Qi deficiency syndrome>blood stasis syndrome>phlegm turbidity syndrome.Six months after operation:blood stasis syndrome>qi deficiency syndrome > phlegm turbidity syndrome.The distribution of syndrome elements in CHD patients before PCI and one week,one month and three months after PCI was significantly different(P<0.05).There was no significant difference in the distribution of syndrome elements between before PCI and six month after PCI in CHD patients(P>0.05).Conclusion:The transformation of syndrome elements in patients with CHD after PCI may begin one week after operation,and the difference between the syndrome elements and the preoperative ones gradually decreases at three months and six months after operation.