心可舒片治疗原发性稳定型微血管性心绞痛38例

Thirty-Eight Cases of Primary Stable Angina Pectoris Treated with Xinkeshu Tablets

目的:观察心可舒片治疗原发性稳定型微血管性心绞痛患者的临床疗效。方法:将77例原发性稳定型微血管性心绞痛患者随机分为治疗组38例和对照组39例。对照组给予常规西药治疗,治疗组在对照组的基础上予心可舒片口服。比较两组患者心绞痛疗效、中医证候疗效及心电图疗效,检测两组患者治疗前后超敏C反应蛋白(hs-C reactive protein,hs-CRP)、白细胞介素-6(interleukin-6,IL-6)水平。结果:对照组有效率为64.10%,治疗组有效率为84.21%,两组患者心绞痛疗效比较,差异有统计学意义(P<0.05)。对照组有效率为66.67%,治疗组有效率为86.84%,两组患者中医证候疗效比较,差异有统计学意义(P<0.05)。对照组有效率为59.00%,治疗组有效率为81.58%,两组患者心电图疗效比较,差异有统计学意义(P<0.05)。两组患者治疗后hs-CRP、IL-6水平低于本组治疗前,且治疗组低于对照组,差异均有统计学意义(P<0.05)。结论:心可舒片能改善原发性稳定型微血管性心绞痛患者临床症状及炎症状态。

Objective:To observe the clinical curative effect of Xinkeshu Tablets(XKST).Methods:A total of 77 patients with primary stable angina pectoris were randomly divided into the treatment group with 38 cases and the control group with 39 cases.The control group was given routine Western medicine treatment,while the treatment group was given XKST orally on the basis of the control group.The effects of angina pectoris,TCM syndromes and electrocardiogram were compared between the two groups.The levels of hs-C reactive protein(hs-CRP) and interleukin-6(IL-6) were measured before and after the treatment.Results:The effective rate of angina was 64.10% in the control group and 84.21% in the treatment group.There was a significant difference between the two groups(P<0.05).The effective rate of the efficacy of TCM syndromes was 66.67% in the control group and 86.84% in the treatment group.There was a significant difference between the two groups in(P<0.05).The effective rate of electrocardiogram of the control group was 59.00%,and that of the treatment group was 81.58%.There was a significant difference between the two groups(P<0.05).The levels of hs-CRP and IL-6 in the two groups after the treatment were lower than those before the treatment,and the treatment group was lower than the control group,and all the differences were statistically significant(P<0.05).Conclusion:XKST can improve the clinical symptoms and inflammatory state of patients with primary stable angina pectoris.