健脾泻肺法对中虚气逆型非糜烂性胃食管反流病患者食管动力的影响

The Influence of Method of Invigorating Spleen and Draining Lung on Esophageal Motility in Patients with Non-Erosive Reflux Disease with Syndrome of Middle-jiao Deficiency and Qi Inversion

目的:观察健脾泻肺法对中虚气逆型非糜烂性胃食管反流病(non-erosive relux disease,NERD)患者食管动力的影响。方法:选择2013年7月至2018年7月在郑州市第七人民医院治疗的NERD患者180例,随机分为观察组和对照组,每组90例。对照组给予艾司奥美拉唑镁肠溶片、多潘立酮片治疗,观察组在对照组治疗的基础上给予健脾泻肺法治疗。结果:观察组有效率87.78%,对照组有效率72.22%,观察组优于对照组,差异有统计学意义(P<0.05);观察组治疗后食管LES静息压优于对照组,差异有统计学意义(P<0.05);两组治疗后UES静息压、UES松弛时间、LES松弛率比较,差异无统计学意义(P>0.05);观察组治疗后食管中段收缩幅、远段收缩幅与对照组比较,差异有统计学意义(P<0.05),两组治疗后食管蠕动速度、吞咽成功率比较,差异无统计学意义(P>0.05)。结论:健脾泻肺法可有效改善中虚气逆型NERD患者的胃食管反流症状,增加食管LES压力和改善体部运动功能,提高患者抗反流能力。

Objective:To observe the influence of method of invigorating spleen and draining lung on esophageal motility in patients with non-erosive reflux disease(NERD)with syndrome of middle-jiao deficiency and qi inversion.Methods:A total of 180 NERD patients treated in Zhengzhou Seventh People′s Hospital from July 2013 to July 2018 were randomly divided into the observation group and the control group,with 90 cases in each group.The control group was treated with Esomeprazole Magnesium Enteric-coated Tablets and Domperidone Tablets,while the observation group was treated with the method of invigorating spleen and draining lung on the basis of the treatment of the control group.Results:The effective rate of the observation group was 87.78%,and that of the control group was 72.22%.The observation group was superior to the control group,and the difference was statistically significant(P<0.05).After the treatment,the resting pressure of LES in the observation group was superior to that in the control group after treatment,and the difference was statistically significant(P<0.05).There were no significant differences in UES resting pressure,UES relaxation time and LES relaxation rate between the two groups after the treatment(P>0.05).There were significant differences in the middle and far esophageal contraction between the two groups after the treatment(P<0.05).There were no significant differences in esophageal peristalsis speed and swallowing success rate between the two groups after treatment(P>0.05).Conclusion:Method of invigorating spleen and draining lung can effectively improve the symptoms of gastroesophageal reflux in NERD patients with syndrome of middle-jiao deficiency and qi inversion,increase the LES pressure of the esophagus,improve the motor function of the esophagus,and improve the anti-reflux ability of the patients.