中药治疗剖宫产术后下肢深静脉血栓临床研究

Clinical Study of Chinese Herbal Medicinein Treating Thrombus after Cesarean Section

目的:观察中药治疗剖宫产术后下肢深静脉血栓(deep vein thrombosis,DVT)的临床疗效。方法:选取2016年11月至2018年12月在本院就诊的剖宫产术后DVT患者98例,按照随机数字表法分为对照组和试验组各49例。两组均采取抗感染、翻身、卧床休息、抬高患肢等基础治疗,对照组给予常规西药治疗,试验组在对照组治疗的基础上给予中药治疗,两组均连续治疗10 d。观察两组患者临床疗效、不良反应、治疗前后疼痛程度、肿胀程度,测定血浆凝血酶原时间(prothrombin time,PT)、纤维蛋白原(fibrinogen,FIB)、血浆黏度(plasma viscosity,PV)等指标。结果:对照组有效率为77. 55%,试验组有效率为95. 92%,两组有效率比较,差异有统计学意义(P <0. 05);治疗后两组DVT患者肿胀及疼痛程度评分均较治疗前降低,差异有统计学意义(P <0. 05),组间比较差异有统计学意义(P <0. 05);治疗后两组FIB、PV降低,PT升高,与治疗前比较差异均有统计学意义(P <0. 05),组间比较差异有统计学意义(P <0. 05);对照组不良反应发生率为14. 28%,试验组不良反应发生率为10. 20%,两组不良反应发生率比较,差异无统计学意义(P> 0. 05)。结论:中药治疗剖宫产术后DVT,有利于缓解患者肿胀、疼痛程度,改善血液流变学指标,安全性较高。

Objective:To observe the clinical curative effect of Chinese herbal medicine treatment on thrombosis after pregnancy operation.Methods:Ninety-eight patients with thrombosis after pregnancy treated in our hospital from November 2016 to December2018 were selected and divided into the control group and the experimental group according to random number table method,with49 cases in each group.The two groups were treated with basic treatment such as anti-infection,turning over,bed rest and raising affected limbs.The control group was additionally treated with conventional Western medicine,while the experimental group was additionally treated with Chinese herbal medicine on the basis of the control group.The two groups were treated continuously for10 days.Then the clinical efficacies,adverse reactions,pain and swelling degrees before and after treatment were observed.The prothrombin time(PT),fibrinogen(FIB)and plasma viscosity(PV)were measured.Results:The effective rate was 77.55%in the control group and 95.92%in the experimental group.There was a significant difference between the two groups(P<0.05).After the treatment,the swelling and pain scores of DVT patients in the two groups were lower than those before the treatment,the difference was statistically significant(P<0.05),and the difference between the two groups was also statistically significant(P<0.05).After the treatment,FIB and PV decreased and PT increased in the two groups,and all the differences were statistically significant(P<0.05),and there was also significant difference between the two groups(P<0.05).The incidence of adverse reactions was 14.28%in the control group and 10.20%in the experimental group.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Chinese herbal medicine treatment has a remarkable efficacy on thrombosis after pregnancy operation,is conducive to relieving swelling and pain,improving hemorheological indicators,and has high safety.