头孢克肟联合氨溴索治疗老年慢性支气管炎急性发作疗效与中医发病机制分析

Clinical Analysis of Cefixime Combined with Ambroxol on Acute Exacerbation of Chronic Bronchitis

目的探讨头孢克肟联合氨溴索治疗老年慢性支气管炎急性发作临床疗效的中医发病机制分析。方法选取2012年4月至2013年12月在我院就诊的老年慢性支气管炎急性发作患者90例,随机分为观察组和对照组,每组各45例。对照组患者使用解痉平喘药、镇咳药、吸氧和头孢克肟进行治疗,观察组患者在对照组的基础上增加使用氨溴索注射液进行雾化吸入治疗。对患者治疗前后的一秒用力呼气容积(FEV1)和一秒用力呼气容积占用力肺活量比值(FEV1%)进行测量,记录患者的临床疗效及不良反应发生情况。结果观察组患者有效率和对照组比较,差异有统计学意义(P<0.05);观察组患者治疗后FEV1和FEV%与对照组比较,差异有统计学意义(P<0.05);两组患者均无严重不良反应发生。结论头孢克肟联合氨溴索治疗老年慢性支气管炎急性发作的临床效果好,对患者的肺功能改善明显,不良反应少,值得临床合理使用。

Objective To study the clinical curative effect of cefixime combined with ambroxol in treatment of elderly patients with acute exacerbation of chronic bronchitis.Methods Selected 90 cases patients with acute exacerbations of chronic bronchitis who doctored in our hospital during 2012 April to 2013 December.Randomly divided it into observation group and control group,each group had 45 cases.Patients in the control group used of antispasmodic drugs,antitussive,oxygen and cefixime to treat,and patients in the observation group to increase the use of ambroxol inhalation therapy on the basis of the control group.The patients before and after the treatment of forced expiratory volume in one second(FEV1)and forced expiratory volume in one second forced vital capacity ratio(FEV1% )were measured,recorded the clinical efficacy and adverse reactions of patients occurred.Results The patients in observation group efficiency compared with the control group,the difference was statistically significant;The observation group after treatment FEV1 and FEV% compared with the control group,the difference was statistically significant;Two groups of patients had no severe adverse reaction.Conclusion Cefixime combined with ambroxol on acute exacerbation has good clinical effect of senile chronic bronchitis,and the lung function of patients improved obviously,it has less adverse reaction and worthy of clinical rational use.