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建立中药小复方精选系统操作技术平台的基本构想 被引量:13

A Basic Concept of Establishing Platforms for Operational Techniques in Systems of Elaborately Selecting Small Prescriptions of Traditional Chinese Medicine
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摘要 本文针对当前中药一、二、三类新药研究存在的问题,就中药精选小复方的定义和特点、筛选的步骤和方法进行了较全面系统的阐述,认为:根据国情和中医药理论特点,中药新药开发必须走先定病证再选药组方的研究之路;应完善和规范中药组合的君、臣、佐、使法则,且据以选药组方;应系统挖掘古方剂学遗产,探索全面建立和全方位利用古代方剂数据库管理系统,向古方剂要新药。本文提出了一种确立小复方具体药物精选的基本原则和思路,以及不同制备工艺、不同剂量配比最优化的考察方法,以求实现中药新药开发的程序化、规范化、定量化和科学化。 Based on generally analyzing the problems coming from the studies of1,2and3categories of new Chinese medicaments,the author makes an overall and systematical statement about the definition,characteristics and selecting steps and methods for small prescriptions of traditional Chinese medicine(TCM)in this article,and thinks that according to the situation in China,the theoretical characteristics of TCM and the objective demands,the study on the development of new Chinese medicaments must take the way of clearing up the syndromes of diseases first and then selecting medicinal materials to make up prescriptions;the principle of monarch,minister,assistant and envoy in the compounds of TCM should be perfected and normalized,on the basis of which the selection of medicinal materials for making up prescriptions can be carried out only;the heritage from the pharmacology of ancient traditional Chinese medical formulae should be explored systematically so as to develop new medicaments,and the methodology of how to overall establish and utilize the management system of the databases of ancient TCM prescriptions is expounded accordingly.In this article the author puts forward the basic principle and thinking of elaborate selection of medicinal materials for small prescriptions as well as an optimal method for the investigation of different preparation techniques and dosage proportion in order to realize the development of new Chinese medicaments by the way of proper programme,standardization,suitable quantity and scientific processes.
作者 梁茂新
出处 《世界科学技术-中药现代化》 2002年第6期31-37,共7页 World Science and Technology(Modernization of Traditional Chinese Medicine)
关键词 中药标准化 药物筛选 中药复方 药物开发 small prescription of Chinese drugs,standardization,drug screening,Technical platform
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参考文献4

  • 1梁茂新,刘杰.影响和提高中药临床疗效的几个关键问题[J].世界科学技术-中药现代化,2002,4(5):18-23. 被引量:1
  • 2宋.唐慎微.重修政和经史证类备用本草.北京:人民卫生出版社,1982.
  • 3明.李时珍.本草纲目.北京:人民卫生出版社,1990.
  • 4梁茂新,黄会生.《普济方》数据库管理系统(计算机软件著作权登记证书软著登字.第0002781号).中华人民共和国国家版权局,1998.

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