规范吸入糖皮质激素治疗哮喘儿童的临床疗效

Effects of Regular Inhalation Corticosteroid Treatment on Children with Asthma

目的探究规范糖皮质激素治疗哮喘儿童的临床疗效。方法回顾性分析2016年3月至2018年3月于我院门诊就诊并确诊为哮喘的98例患儿的临床资料,将持续性吸入糖皮质激素的患儿纳入规范组(n=47),将非持续性吸入糖皮质激素的患儿纳入非规范组(n=51)。治疗期间定期随访,于治疗后6个月和1年对比两组患儿的治疗效果,停药后,随访一年,观察两组患儿哮喘复发情况并分析相关的危险因素。结果治疗后,规范组临床症状评分明显低于非规范组(P<0.05)。治疗6个月及1年后,规范组PEF和FEV1均明显升高,且与治疗前相比,差异具有统计学意义(P<0.05)。治疗1年后,规范组PEF和FEV1均明显高于非规范组(P<0.05)。停药1年后,规范组哮喘复发率为12.77%,非规范组哮喘复发率为33.33%,规范组复发率明显低于非规范组,差异具有统计学意义(P<0.05)。结论规范吸入糖皮质激素治疗哮喘儿童临床效果更佳,能有效提高患儿肺功能,且停药后复发率低,该方案值得临床推广。

Objective To explore the effects of regular inhalation corticosteroid treatment on children.Methods Retrospective analysis of a total of 98 children with asthma treated in the outpatient department of the hospital from March 2016 to March 2018 were performed.According to the results of follow-up,children receiving persistent inhalation of glucocorticoids were included in the standard group(n=47)while those receiving non-persistent inhalation of glucocorticoids were included in the non-standard group(n=51).The therapeutic effects were compared between the two groups at 6 months and 1 year after treatment.Both groups were followed up for one year after drug withdrawal to observe the recurrence of asthma and analyze the related risk factors.Results The clinical symptom scores in the standard group were significantly lower than those in the non-standard group after treatment(P<0.05).PEF and FEV1 in the standard group were significantly increased after treatment after 6 months and 1 year of treatment(P<0.05).The PEF and FEV1 in the standard group were significantly higher than those in the control group after 1 year of treatment(P<0.05).The recurrence rate of asthma in the standard group was significantly lower than that in the non-standard group at 1 year after drug withdrawal(12.77%vs 33.33%)(P<0.05).Conclusion The effect of regular inhalation corticosteroid treatment is better for children with asthma.It can effectively improve the lung function in children,and the recurrence rate after drug withdrawal is low.