摘要
实验研究了以氯化苄为原料合成药物中间体苯基丙酮的新工艺。该工艺由苄基氯化锌和苯基丙酮的 2步合成反应组成。优化的工艺条件为 :原料n(氯化苄 )∶n(Zn)∶n(乙酐 )为 1∶1.2∶2 .5 ;苄基氯化锌的合成温度 60～ 65℃ ,反应时间 3h ;苯基丙酮合成温度 3 0～ 3 5℃ ,反应时间 5h ,总收率 72 %。
New progress for phenylacetone synthesis from organic zinc reagent and acetic anhydride was studied. The suitable progress was determined based on experiment results under various conditions such as mole rate, reaction temperature and time. The over yield of phenylacetone achieved 72%.
出处
《江苏化工》
2002年第6期36-37,41,共3页
Jiangsu Chemical Industry
