摘要
以猪去氧胆酸甲酯4为原料,乙酰链甾醇11为关键中间体和改进的Sharpless不对称双羟化反应为关键步骤,经9步反应,以56％的总收率和100％de高立体选择性地合成了LXRs激动剂24S,25-环氧胆固醇1.并通过1合成了LXRα亚型选择性激动剂5α,6α:24S,25-双环氧胆固醇2以及新配体5β,6β24S,25-双环氧胆固醇3.
出处
《科学通报》
EI
CAS
CSCD
北大核心
2002年第24期1868-1875,共8页
Chinese Science Bulletin
基金
国家自然科学基金(批准号:20072047)
中国科学院上海有机化学研究所生命有机化学国家重点实验室基金
第三军医大学科研基金资助项目
重庆市攻关项目(批准号:6617).
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