刺激响应型肽自组装及其应用

Stimuli-Responsive Peptides Self-Assembly and Its Application

肽自组装体由于具有结构稳定、易调控、生物相容性好、可生物降解等优点,在构筑新型材料及生物医药领域表现出了巨大潜力。本文介绍了肽自组装的概念、机理和应用,详细归纳了刺激响应型肽自组装的研究进展;按照刺激源的不同将刺激响应型肽自组装分为pH响应型肽自组装、温度响应型肽自组装、溶剂响应型肽自组装、光响应型肽自组装、超声波响应型肽自组装以及离子响应型肽自组装;列举了肽自组装在药物控释、脊髓损伤修复、仿酶催化、生物模板等领域的应用。最后,基于目前肽自组装存在的一些问题(如影响肽自组装结构的外界因素不易精准把控、自组装的研究与生命科学领域的交叉程度低等)对肽自组装的发展做了展望。

Peptides self-assembly has great potential applications in the field of biomedicine and construction of new materials for the advantages of stable structure, easy control, and good biocompatibility and biodegradability. In this paper,the progress in peptides self-assembly is systematically reviewed,including the conception,mechanism and applications,focusing on the stimuli-responsive peptides self-assembly. According to the difference of stimuli,stimuli-responsive peptides self-assembly can be classified into pH-responsive selfassembly, temperature-responsive self-assembly, solvent-responsive self-assembly, light-responsive selfassembly, ultrasonic responsive self-assembly,and ion-responsive self-assembly. The applications of peptides self -assembly in drug release carriers,the repair of spinal cord injury,biomimetic enzyme catalysis,and biological template are listed in detail. Finally,the problems of peptides self-assembly research,such as difficult control of the external factors that affect the structure of assembly and the low degree of overlap between peptides selfassembly and life sciences,are analyzed,and the future development of stimuli-responsive peptides self-assembly is prospected.