新型多取代(口恶)唑类化合物的合成

Synthesis of Novel Polysubstituted Oxazole Compounds

唑类杂环化合物具有广泛的生物活性,如杀菌、杀虫、抗植物病毒、除草等。目前,对该类化合物的合成与生物活性的研究是合成化学研究热点之一。由α-乙酰基环丙烷类化合物和异氰基乙酸乙酯在Cu2O催化下合成了一系列新型多取代(口恶)唑类化合物,通过核磁共振、红外、元素分析、质谱分析对所得化合物进行了表征,并对该反应机理进行了探讨。该方法操作简单,在较温和的条件下合成了多取代(口恶)唑类化合物。

Oxazdiazole derivatives contained wide biology activity in insecticidal,fungicidal,antiviral and herbicidal activities.At present,the research on synthesis and biological activity of these compounds are still one of the hot topics in synthetic chemistry.The synthesis of novel polysubstituted oxazole compounds were developed fromα-acetyl cyclopropanes and isocyanoacetic acid ethyl ester,under the Cu2 O catalyst,and the products were confirmed by NMR,IR,MS and elements analysis.Moreover,a mechanism for the reaction was proposed.The polysubstituted oxazole compounds were synthesized under mild conditions with simple process.