邻碘酰苯甲酸氧化乙偶姻合成丁二酮

Synthesis of Butanedione by Oxidizing Acetoin with o-Iodoxybenzoic Acid

以邻碘酰苯甲酸(IBX)为氧化剂,对乙偶姻氧化合成丁二酮的反应进行研究。考察了影响反应的因素,得出了其优化反应条件为:邻碘酰苯甲酸与乙偶姻的物质的量比为1.2∶1,用叔丁醇作溶剂,反应温度为70℃,反应时间40 min,产率达95%。氧化剂和溶剂均可以回收利用。

Butanedione was synthesized by oxidizing acetoin with o-iodoxybenzoic acid as oxidant.The effects of various factors on the reaction were studied.The optimal reaction conditions are:the molar ratio of o-iodoxybenzoic acid to acetoin was 1.2∶1,tert-butanol as solvent with a reaction temperature of 70℃and a reaction time of 40 min.Under the optimal conditions,the yield can be as high as 95%.The oxidant and solvent could be recycled for reuse.