Ⅴ.N^4-[5′-(3′-甲硫基-6′-甲基)-1′,2′,4′-三嗪基]-3-甲硫基-5-氧代-6-甲基-4,5-二氢-1,2,4-三嗪的胺解反应

Ⅴ.AMINOLYSIS OF N^4-[5′-(3′-METHYLMERCAPTO-6′-METHYL)-1′,2′,4′-TRIAZINYL]-3-METHYLMERCAPTO-5-OXO-6-METHYL-4,5-DIHYDRO-1,2,4-TRIAZINE

N^4-[5′-(3′-甲硫基-6′-甲基)-1′,2′,4′-三嗪基-3-甲硫基-5-氧代-6-甲基-4,5-二氢-1,2,4-三嗪(Ⅱ)在乙醇中与一系列胺反应,得3-甲硫基-5-取代胺基-6-甲基-1,2,4-三嗪(Ⅲ_(a-h))及3-甲硫基-5-羟基-6-甲基-1,2,4-三嗪(Ⅰ);Ⅱ在同样条件下,与碱性弱或空间障碍较大的对硝基苯胺、邻氯苯胺及邻甲苯胺不发生反应;Ⅱ与氨,异丁胺反应,尚得到3-取代胺基-5-羟基-6-甲基-1,2,4-三嗪(Ⅳ_(a,b)).

ABSTRACT When aminolysis of N^4-[5′-(3′-methylmercapto-6′-methyl)-1′,2′,4′-triazinyl]-3-methyl-mercapto-5-oxo-6-methyl-4,5-dihydro-1,2,4-triazine (Ⅱ) with a series of aliphatic and aromatic amines was conducted in hot ethanol,5-substituted amino-3-methylmercapto-6-methyl-1,2,4-triazines (Ⅲ_(a-h)) and 3-methylmercapto-5-hydroxy-6-methyl-1,2,4-triazine (Ⅰ) were obtained (Table 1).No reaction took place with p-nitroaniline,ο-chloroaniline,or with ο-toluidine.When compound (Ⅱ) reacted with isobutylamine or with ammonia in hot ethanol,3-isobutyl-amino-5-hydroxy-6-methyl-1,2,4-triazine (Ⅳ_a) or 3-amino-5-hydroxy-6-methyl-1,2,4-triazine (Ⅳ_b) was obtained respectively in addition to the 5-substituted amino-3-methyhnercapto-6-methyl-1,2,4-triazine (Ⅲ_(a,e)) and 3-methylmercapto-5-hydroxy-6-methyl-1,2,4-triazine (Ⅰ).