尿毒症透析及非透析患者血清瘦素水平及临床意义

The clinical significance on serum leptin levels in dialysis and nondialysis uremia patients

目的 观察慢性肾小球肾炎肾功能正常、肾功能衰竭非透析、肾功能衰竭透析患者血清瘦素水平及临床意义。方法 以放射免疫法测定正常对照组及观察组患者血清瘦素浓度,生物化学方法测定血肌酐、血红蛋白、血浆白蛋白、血脂。结果 肾功能衰竭非透析组与慢性肾小球肾炎肾功能正常组比较血清瘦素浓度升高具有显著性差异P<0.05,肾功能衰竭非透析组与肾功能衰竭透析组比较血清瘦素浓度升高无显著性差异P>0.05,肾功能衰竭透析组与慢性肾小球肾炎肾功能正常组比较血清瘦素浓度升高具有显著性差异P<0.05;慢性肾功能衰竭患者血清瘦素与血红蛋白呈负相关(P<0.05),而血清瘦素与血浆白蛋白、血脂之间无相关性。结论 慢性肾功能衰竭患者血清瘦素浓度增加,与肾功能关系密切,可能是造成尿毒症患者营养不良的因素之一。

Objective To observe the mechanism of chronic renal failure related with serum leptin levels. Methods Serum leptin levels of chronic renal failure were determined by isotopic radioimmunoassay. Serum creatine, hemoglobin were determined by biochemical measurements. Results Compared with the control group and normal renal function group , serum leptin levels was higher in non - dialysis and dialysis uremia patients. There were nagtive relationship between leptin and hemoglobin . There are no significant in non - dialysis and dialysis uremia patients. Serum leptin levels are no related with Alb,TG,LDL,HDL. Conclusion Serum leptin levels are higher in the uremia non- dialysis patients and the dialysed patients. Primary dialysis may not able to clean leptin from blood.