EB病毒基因检测对良恶性胸腔积液诊断价值

A Study of the Values of EBVG in Differentiating Malignant from Non-Malignant Pleural Effusions

目的 研究胸腔积液 EB病毒基因 (EBVG)在良、恶性胸液中的鉴别诊断 ,并与结核基因 (TBG)进行对比。方法 用聚合酶链反应 (PCR)检测胸腔积液 EBVG与 TBG。结果 6 8例患者 :(1)结胸组 38例 :EBVG 9例(2 3.7% ) ,TBG2 9例 (76 .3% ) ,(2 )恶胸组 30例 :EBVG 2 4例 (80 % ) ,TBG 6例 (2 0 % )。基因检测的灵敏度为 0 .89,特异度 0 .90 ,正确率 0 .91。结论 胸腔积液 EBVG检测 。

Objective To study the value of EBVG in differentiating maglignant from non malignant pleural effusions.Methods Sixty eight patients of pleural effusion were classified into two groups: Group 1: tube culosis pleural group (n=38) and Group 2: malignant pleural group (n=30). The two groups were compared in their EBVG and TBG levels.Results Nine of 38 (23.7%) in Group 1 had EBVG and 29 (76.3%) had TBG. In comparison, 24 out of 30 (80%) in Group 2 had EBVG and 6 had TBG (30%). The diagnostic sensitivity was 0.89; specificity was 0.90. The overall accuracy was 0.91.Conclusion The detection of EBVG can be used as a supportive measure in the diagnosis of malignant pleural effusions.