摘要
Objective To document morphological changes in hepatic microcirculation in liver tissue with hepatitis B and the pathogenesis of hepatic microcirculatory disturbances.Methods Liver tissue samples were obtained from patients with hepatitis B by liver biopsy. These samples were examined with a light microscope and transmission electron microscope. Results Hepatic microcirculatory disturbances existed in patients with hepatitis B, including those with normal liver function, manifested by red blood cell aggregation in sinusoids seen under light microscope and sinusoidal capillarization seen under electron microscope. Weibel-Palade bodies in sinusoidal endothelial cells were seen in 26 out of 53 cases. Intimate contacts were found between lymphocyte/Kupffer cells and sinusoidal endothelial cells. Conclusions Hepatic microcirculatory disturbances exist in patients with hepatitis B .The appearance of Weibel-Palade bodies in sinusoidal endothelial cells may be a key step in the development of hepatic microcirculatory disturbances.
目的 观察慢性乙型肝炎的肝脏微循环变化并探讨其发生机制。方法 对 141例慢性乙型肝炎病人进行肝活检 ,活检组织行光镜观察 ,其中 5 3例还进行了电镜观察。结果 慢性乙型肝炎患者 ,包括肝功能正常者存在肝脏微循环障碍 ,在光镜下主要表现为肝窦腔内红细胞聚集 ,电镜下主要表现为肝窦毛细血管化。电镜观察的 5 3例中有 2 6例肝窦内皮细胞中发现Weibel Palade小体。淋巴细胞、枯否氏细胞及肝窦内皮细胞间发生密切联系。结论 慢性乙型肝炎患者存在肝脏微循环障碍。肝窦内皮细胞中出现Weibel Palade小体可能是肝脏微循环障碍发生的关键环节。
