摘要
OBJECTIVE: To investigate a non-invasive, effective and rapid mode of detecting the recurrence of bladder cancer during follow-up. METHODS: Ninety patients following transurethral resection of bladder tumor (TURBt) surgery were recruited from January 1998 to March 2000. Standard ELISA was used to determine the quantity of nuclear matrix protein (NMP-22) in urine of all bladder cancer patients during their follow-up periods. Urine bladder tumor antigen (BTA) stat test was simultaneously performed and followed by cystoscopy. RESULTS: The total positive rates of urinary NMP-22 and BTA stat test were 76.7% (33/43) and 67.4% (29/43), respectively. Comparatively, this positive rate would increase to 93.0% (40/43) when the combination of both urine NMP-22 and BTA test were adopted. CONCLUSION: Examination of NMP-22 in urine is a rapid and effective way to detect the recurrence of bladder cancer. If combined with BTA test, NMP-22 may be used as a non-invasive method in surveillance of recurring of bladder cancer, which may reduce the frequency of patients needing to undergo conventional invasive cystoscopy.
目的 探讨一种无创 ,快速 ,高效便捷的监测膀胱肿瘤复发的方法用于肿瘤术后的随访。方法 采用标准ELISA法检测病人尿中的核基质蛋白 2 2 (NMP 2 2 )值 ,并对患者进行尿液膀胱肿瘤抗原 (BTAstat)测定 ,膀胱镜检及病理检测以明确有无肿瘤复发。结果 与膀胱镜检及活检结果相比较 ,尿的NMP 2 2检测可发现 76 7% (33/ 4 3)复发的病例 ,尿的BTAstat可发现 6 7 4 % (2 9/ 4 3)复发的病例。若将两项检测的结果综合考虑 ,则检测的准确率达 93 0 % (40 / 4 3)。结论 尿的NMP 2 2检测为一种快速 ,高效 ,便捷的监测膀胱肿瘤复发的方法 ,若同BTAStat检测联合使用 ,会提高其准确率 。
